MicroRNAs regulate and provide robustness to the myogenic transcriptional network

Jeffrey Gagan, Bijan K. Dey, Anindya Dutta

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

The genetics of skeletal muscle lineage commitment are deceptively complicated. MyoD overexpression is sufficient to convert fibroblasts into skeletal muscle myotubes. In vivo, there are a number of different steps of differentiation that require a large network of transcription factors that control differentiation and homeostasis of skeletal muscle progenitors. Each transcription factor has been shown to have the ability to promote the next factor in the cascade, but the mechanisms regulating the transitions remain incomplete. Recently, microRNAs have been shown to be important for a large number of developmental and oncogenic processes. In this review, we will discuss recent advances in the understanding of how microRNA is critical for skeletal muscle development by interacting with protein-coding genes that had previously been shown to be important for myogenesis.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume12
Issue number3
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Gene Regulatory Networks
MicroRNAs
Skeletal Muscle
Muscle Development
Transcription Factors
Skeletal Muscle Fibers
Homeostasis
Fibroblasts
Proteins

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

MicroRNAs regulate and provide robustness to the myogenic transcriptional network. / Gagan, Jeffrey; Dey, Bijan K.; Dutta, Anindya.

In: Current Opinion in Pharmacology, Vol. 12, No. 3, 06.2012, p. 383-388.

Research output: Contribution to journalReview article

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