Microscopic venous invasion is associated with disease free and cancer free survival in renal cell carcinoma

O. Sanli, O. U. Zorba, S. Erdem, M. Tezer, I. Kilicarslan, T. Esen, M. Tunc

Research output: Contribution to journalArticle

Abstract

Aim. The aim of this study was to investigate the significance of microscopic venous invasion (MVI) as a prognostic factor for patients with renal cell carcinoma (RCC). Methods. The present study included 220 patients with non-metastatic RCC who underwent radical nephrectomy (RN). MVI was defined by the presence of a cancer cell in blood vessels based on microscopic examination of hematoxylin-eosin stained specimens. The impact of MVI on disease progression and survival after 37 (6-190) months of median follow-up and its correlation with known clinicopathological features were studied. Survival analyses using Kaplan-Meier and log-rank models for univariate comparisons and Cox proportional hazards model for multivariate analyses were performed. Results. MVI was found in 68 patients (30.8%), and of these, 26 (38.2%) developed a tumor recurrence and 16 (23.5%) died of cancer progression, whereas only 18 (11.8%) of the remaining 152 patients without MVI presented with disease-recurrence and 8 (5.3%) died of cancer. In the multivariate analysis, MVI (P=0.014) Fuhrman's grade (P=0.028), and sarcomatoid differentiation (SD) (P=0.01) were the factors predicted a decreased disease-free survival (DFS). Meanwhile, MVI (P=0.04) and SD (P=0.029) were also found to be predictor of cancer specific survival (CSS) with necrosis (P=0.037) in multivariate analysis. Conclusions. The present study showed that MVI is associated with the vast majority of the adverse pathological features related with RCC. Furthermore, it was found to be an independent clinical prognostic factor for DFS and CSS.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalMinerva Urologica e Nefrologica
Volume62
Issue number4
StatePublished - Dec 1 2010

Fingerprint

Renal Cell Carcinoma
Survival
Neoplasms
Multivariate Analysis
Disease-Free Survival
Recurrence
Hematoxylin
Eosine Yellowish-(YS)
Survival Analysis
Nephrectomy
Proportional Hazards Models
Blood Vessels
Disease Progression
Necrosis

Keywords

  • Carcinoma, renal cell
  • Prognosis
  • Veins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sanli, O., Zorba, O. U., Erdem, S., Tezer, M., Kilicarslan, I., Esen, T., & Tunc, M. (2010). Microscopic venous invasion is associated with disease free and cancer free survival in renal cell carcinoma. Minerva Urologica e Nefrologica, 62(4), 347-353.

Microscopic venous invasion is associated with disease free and cancer free survival in renal cell carcinoma. / Sanli, O.; Zorba, O. U.; Erdem, S.; Tezer, M.; Kilicarslan, I.; Esen, T.; Tunc, M.

In: Minerva Urologica e Nefrologica, Vol. 62, No. 4, 01.12.2010, p. 347-353.

Research output: Contribution to journalArticle

Sanli, O, Zorba, OU, Erdem, S, Tezer, M, Kilicarslan, I, Esen, T & Tunc, M 2010, 'Microscopic venous invasion is associated with disease free and cancer free survival in renal cell carcinoma', Minerva Urologica e Nefrologica, vol. 62, no. 4, pp. 347-353.
Sanli, O. ; Zorba, O. U. ; Erdem, S. ; Tezer, M. ; Kilicarslan, I. ; Esen, T. ; Tunc, M. / Microscopic venous invasion is associated with disease free and cancer free survival in renal cell carcinoma. In: Minerva Urologica e Nefrologica. 2010 ; Vol. 62, No. 4. pp. 347-353.
@article{e1737b743160492b88532363eb11878c,
title = "Microscopic venous invasion is associated with disease free and cancer free survival in renal cell carcinoma",
abstract = "Aim. The aim of this study was to investigate the significance of microscopic venous invasion (MVI) as a prognostic factor for patients with renal cell carcinoma (RCC). Methods. The present study included 220 patients with non-metastatic RCC who underwent radical nephrectomy (RN). MVI was defined by the presence of a cancer cell in blood vessels based on microscopic examination of hematoxylin-eosin stained specimens. The impact of MVI on disease progression and survival after 37 (6-190) months of median follow-up and its correlation with known clinicopathological features were studied. Survival analyses using Kaplan-Meier and log-rank models for univariate comparisons and Cox proportional hazards model for multivariate analyses were performed. Results. MVI was found in 68 patients (30.8{\%}), and of these, 26 (38.2{\%}) developed a tumor recurrence and 16 (23.5{\%}) died of cancer progression, whereas only 18 (11.8{\%}) of the remaining 152 patients without MVI presented with disease-recurrence and 8 (5.3{\%}) died of cancer. In the multivariate analysis, MVI (P=0.014) Fuhrman's grade (P=0.028), and sarcomatoid differentiation (SD) (P=0.01) were the factors predicted a decreased disease-free survival (DFS). Meanwhile, MVI (P=0.04) and SD (P=0.029) were also found to be predictor of cancer specific survival (CSS) with necrosis (P=0.037) in multivariate analysis. Conclusions. The present study showed that MVI is associated with the vast majority of the adverse pathological features related with RCC. Furthermore, it was found to be an independent clinical prognostic factor for DFS and CSS.",
keywords = "Carcinoma, renal cell, Prognosis, Veins",
author = "O. Sanli and Zorba, {O. U.} and S. Erdem and M. Tezer and I. Kilicarslan and T. Esen and M. Tunc",
year = "2010",
month = "12",
day = "1",
language = "English (US)",
volume = "62",
pages = "347--353",
journal = "Minerva Urologica e Nefrologica",
issn = "0393-2249",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "4",

}

TY - JOUR

T1 - Microscopic venous invasion is associated with disease free and cancer free survival in renal cell carcinoma

AU - Sanli, O.

AU - Zorba, O. U.

AU - Erdem, S.

AU - Tezer, M.

AU - Kilicarslan, I.

AU - Esen, T.

AU - Tunc, M.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Aim. The aim of this study was to investigate the significance of microscopic venous invasion (MVI) as a prognostic factor for patients with renal cell carcinoma (RCC). Methods. The present study included 220 patients with non-metastatic RCC who underwent radical nephrectomy (RN). MVI was defined by the presence of a cancer cell in blood vessels based on microscopic examination of hematoxylin-eosin stained specimens. The impact of MVI on disease progression and survival after 37 (6-190) months of median follow-up and its correlation with known clinicopathological features were studied. Survival analyses using Kaplan-Meier and log-rank models for univariate comparisons and Cox proportional hazards model for multivariate analyses were performed. Results. MVI was found in 68 patients (30.8%), and of these, 26 (38.2%) developed a tumor recurrence and 16 (23.5%) died of cancer progression, whereas only 18 (11.8%) of the remaining 152 patients without MVI presented with disease-recurrence and 8 (5.3%) died of cancer. In the multivariate analysis, MVI (P=0.014) Fuhrman's grade (P=0.028), and sarcomatoid differentiation (SD) (P=0.01) were the factors predicted a decreased disease-free survival (DFS). Meanwhile, MVI (P=0.04) and SD (P=0.029) were also found to be predictor of cancer specific survival (CSS) with necrosis (P=0.037) in multivariate analysis. Conclusions. The present study showed that MVI is associated with the vast majority of the adverse pathological features related with RCC. Furthermore, it was found to be an independent clinical prognostic factor for DFS and CSS.

AB - Aim. The aim of this study was to investigate the significance of microscopic venous invasion (MVI) as a prognostic factor for patients with renal cell carcinoma (RCC). Methods. The present study included 220 patients with non-metastatic RCC who underwent radical nephrectomy (RN). MVI was defined by the presence of a cancer cell in blood vessels based on microscopic examination of hematoxylin-eosin stained specimens. The impact of MVI on disease progression and survival after 37 (6-190) months of median follow-up and its correlation with known clinicopathological features were studied. Survival analyses using Kaplan-Meier and log-rank models for univariate comparisons and Cox proportional hazards model for multivariate analyses were performed. Results. MVI was found in 68 patients (30.8%), and of these, 26 (38.2%) developed a tumor recurrence and 16 (23.5%) died of cancer progression, whereas only 18 (11.8%) of the remaining 152 patients without MVI presented with disease-recurrence and 8 (5.3%) died of cancer. In the multivariate analysis, MVI (P=0.014) Fuhrman's grade (P=0.028), and sarcomatoid differentiation (SD) (P=0.01) were the factors predicted a decreased disease-free survival (DFS). Meanwhile, MVI (P=0.04) and SD (P=0.029) were also found to be predictor of cancer specific survival (CSS) with necrosis (P=0.037) in multivariate analysis. Conclusions. The present study showed that MVI is associated with the vast majority of the adverse pathological features related with RCC. Furthermore, it was found to be an independent clinical prognostic factor for DFS and CSS.

KW - Carcinoma, renal cell

KW - Prognosis

KW - Veins

UR - http://www.scopus.com/inward/record.url?scp=79952053378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952053378&partnerID=8YFLogxK

M3 - Article

C2 - 20944535

AN - SCOPUS:79952053378

VL - 62

SP - 347

EP - 353

JO - Minerva Urologica e Nefrologica

JF - Minerva Urologica e Nefrologica

SN - 0393-2249

IS - 4

ER -