Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography

Yong Huang, Dedi Tong, Shan Zhu, Lehao Wu, Zuhaib Ibrahim, Wp Andrew Lee, Gerald Brandacher, Jin U. Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Vascular and microvascular anastomosis are critical components of reconstructive microsurgery, vascular surgery and transplant surgery. Imaging modality that provides immediate, real-time in-depth view and 3D structure and flow information of the surgical site can be a great valuable tool for the surgeon to evaluate surgical outcome following both conventional and innovative anastomosis techniques, thus potentially increase the surgical success rate. Microvascular anastomosis for vessels with outer diameter smaller than 1.0 mm is extremely challenging and effective evaluation of the outcome is very difficult if not impossible using computed tomography (CT) angiograms, magnetic resonance (MR) angiograms and ultrasound Doppler. Optical coherence tomography (OCT) is a non-invasive high-resolution (micron level), high-speed, 3D imaging modality that has been adopted widely in biomedical and clinical applications. Phaseresolved Doppler OCT that explores the phase information of OCT signals has been shown to be capable of characterizing dynamic blood flow clinically. In this work, we explore the capability of Fourier domain Doppler OCT as an evaluation tool to detect commonly encountered post-operative complications that will cause surgical failure and to confirm positive result with surgeon’s observation. Both suture and cuff based techniques were evaluated on the femoral artery and vein in the rodent model.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
PublisherSPIE
ISBN (Print)9780819498472
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII - San Francisco, CA, United States
Duration: Feb 3 2014Feb 5 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8934
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
CountryUnited States
CitySan Francisco, CA
Period2/3/142/5/14

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Keywords

  • Fourier domain Doppler optical coherence tomography
  • Microvascular anastomosis
  • Reconstructive surgery

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Huang, Y., Tong, D., Zhu, S., Wu, L., Ibrahim, Z., Lee, W. A., ... Kang, J. U. (2013). Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII [893425] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8934). SPIE. https://doi.org/10.1117/12.2041975