Microvascular invasion and survival in cancer of the oral cavity and oropharynx

L. G. Close, P. M. Brown, M. F. Vuitch, J. Reisch, S. D. Schaefer

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Although the presence of squamous cell carcinoma within the pretumoral vascular spaces of primary lesions of the oral cavity and oropharynx has been statistically linked to regional lymph node metastases, the association of this finding with disease control and survival has not been well demonstrated. To evaluate this relationship, we have reviewed the clinical and histopathologic features of 65 consecutive cases of previously untreated T2 or greater squamous cell carcinoma of these sites managed by simultaneous surgical treatment of the primary lesion and regional lymph nodes. Of all the histopathologic features of the primary lesion studied, vascular invasion had the greatest impact on survival, as confirmed by both univariate and multivariate analysis. In addition, vascular invasion correlated statistically with local recurrence, neck recurrence, and distant metastasis.

Original languageEnglish (US)
Pages (from-to)1304-1309
Number of pages6
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume115
Issue number11
StatePublished - 1989

Fingerprint

Oropharyngeal Neoplasms
Mouth Neoplasms
Blood Vessels
Mouth
Squamous Cell Carcinoma
Lymph Nodes
Neoplasm Metastasis
Recurrence
Oropharynx
Neck
Multivariate Analysis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Microvascular invasion and survival in cancer of the oral cavity and oropharynx. / Close, L. G.; Brown, P. M.; Vuitch, M. F.; Reisch, J.; Schaefer, S. D.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 115, No. 11, 1989, p. 1304-1309.

Research output: Contribution to journalArticle

Close, L. G. ; Brown, P. M. ; Vuitch, M. F. ; Reisch, J. ; Schaefer, S. D. / Microvascular invasion and survival in cancer of the oral cavity and oropharynx. In: Archives of Otolaryngology - Head and Neck Surgery. 1989 ; Vol. 115, No. 11. pp. 1304-1309.
@article{36a8186d930c4240865ba8dffbb32e5a,
title = "Microvascular invasion and survival in cancer of the oral cavity and oropharynx",
abstract = "Although the presence of squamous cell carcinoma within the pretumoral vascular spaces of primary lesions of the oral cavity and oropharynx has been statistically linked to regional lymph node metastases, the association of this finding with disease control and survival has not been well demonstrated. To evaluate this relationship, we have reviewed the clinical and histopathologic features of 65 consecutive cases of previously untreated T2 or greater squamous cell carcinoma of these sites managed by simultaneous surgical treatment of the primary lesion and regional lymph nodes. Of all the histopathologic features of the primary lesion studied, vascular invasion had the greatest impact on survival, as confirmed by both univariate and multivariate analysis. In addition, vascular invasion correlated statistically with local recurrence, neck recurrence, and distant metastasis.",
author = "Close, {L. G.} and Brown, {P. M.} and Vuitch, {M. F.} and J. Reisch and Schaefer, {S. D.}",
year = "1989",
language = "English (US)",
volume = "115",
pages = "1304--1309",
journal = "JAMA Otolaryngology - Head and Neck Surgery",
issn = "2168-6181",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Microvascular invasion and survival in cancer of the oral cavity and oropharynx

AU - Close, L. G.

AU - Brown, P. M.

AU - Vuitch, M. F.

AU - Reisch, J.

AU - Schaefer, S. D.

PY - 1989

Y1 - 1989

N2 - Although the presence of squamous cell carcinoma within the pretumoral vascular spaces of primary lesions of the oral cavity and oropharynx has been statistically linked to regional lymph node metastases, the association of this finding with disease control and survival has not been well demonstrated. To evaluate this relationship, we have reviewed the clinical and histopathologic features of 65 consecutive cases of previously untreated T2 or greater squamous cell carcinoma of these sites managed by simultaneous surgical treatment of the primary lesion and regional lymph nodes. Of all the histopathologic features of the primary lesion studied, vascular invasion had the greatest impact on survival, as confirmed by both univariate and multivariate analysis. In addition, vascular invasion correlated statistically with local recurrence, neck recurrence, and distant metastasis.

AB - Although the presence of squamous cell carcinoma within the pretumoral vascular spaces of primary lesions of the oral cavity and oropharynx has been statistically linked to regional lymph node metastases, the association of this finding with disease control and survival has not been well demonstrated. To evaluate this relationship, we have reviewed the clinical and histopathologic features of 65 consecutive cases of previously untreated T2 or greater squamous cell carcinoma of these sites managed by simultaneous surgical treatment of the primary lesion and regional lymph nodes. Of all the histopathologic features of the primary lesion studied, vascular invasion had the greatest impact on survival, as confirmed by both univariate and multivariate analysis. In addition, vascular invasion correlated statistically with local recurrence, neck recurrence, and distant metastasis.

UR - http://www.scopus.com/inward/record.url?scp=0024421333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024421333&partnerID=8YFLogxK

M3 - Article

C2 - 2803710

AN - SCOPUS:0024421333

VL - 115

SP - 1304

EP - 1309

JO - JAMA Otolaryngology - Head and Neck Surgery

JF - JAMA Otolaryngology - Head and Neck Surgery

SN - 2168-6181

IS - 11

ER -