Abstract
The synthesis of benzo[b][1,4]thiazin-3(4H)-one derivatives in a simple and efficient method from the one-pot reaction of substituted 2-chlorobenzenthiols, chloroacetyl chloride, and primary amines via Smiles rearrangement under microwave irradiation gave high yields (65-92%) of the products with short reaction time (15-20 min).
Original language | English (US) |
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Pages (from-to) | 9669-9674 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 64 |
Issue number | 41 |
DOIs | |
State | Published - Oct 6 2008 |
Keywords
- 2-Chlorobenzenethiol
- Benzo[b][1,4]thiazin-3(4H)-one
- Microwave
- One-pot
- Smiles rearrangement
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry