Middle Ear “Adenoma”: a Neuroendocrine Tumor with Predominant L Cell Differentiation

Sylvia L. Asa; Knarik Arkun; Arthur S. Tischler; Adnan Qamar; Fang Ming Deng; Bayardo Perez-Ordonez; Ilan Weinreb; Justin A. Bishop; Bruce M. Wenig; Ozgur Mete

doi:10.1007/s12022-021-09684-z

Middle Ear “Adenoma”: a Neuroendocrine Tumor with Predominant L Cell Differentiation

Sylvia L. Asa, Knarik Arkun, Arthur S. Tischler, Adnan Qamar, Fang Ming Deng, Bayardo Perez-Ordonez, Ilan Weinreb, Justin A. Bishop, Bruce M. Wenig, Ozgur Mete

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This morphological and immunohistochemical study demonstrates that tumors currently known as “middle ear adenomas” are truly well-differentiated epithelial neuroendocrine tumors (NETs) composed of cells comparable to normal intestinal L cells, and therefore, these tumors resemble hindgut NETs. These tumors show consistent expression of glucagon, pancreatic polypeptide, PYY, and the transcription factor SATB2, as well as generic neuroendocrine markers and keratins. The same L cell markers are expressed by cells within the normal middle ear epithelium. These markers define a valuable immunohistochemical profile that can be used for differential diagnosis of middle ear neoplasms, particularly in distinguishing epithelial NETs from paragangliomas. The discovery of neuroendocrine cells expressing the same markers in non-neoplastic middle ear mucosa opens new areas of investigation into the physiology of the normal middle ear and the pathophysiology of middle ear disorders.

Original language	English (US)
Pages (from-to)	433-441
Number of pages	9
Journal	Endocrine Pathology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1007/s12022-021-09684-z
State	Published - Dec 2021

Keywords

L cell
Middle ear adenoma
Neuroendocrine tumor

ASJC Scopus subject areas

Pathology and Forensic Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Middle Ear “Adenoma”: a Neuroendocrine Tumor with Predominant L Cell Differentiation",

abstract = "This morphological and immunohistochemical study demonstrates that tumors currently known as “middle ear adenomas” are truly well-differentiated epithelial neuroendocrine tumors (NETs) composed of cells comparable to normal intestinal L cells, and therefore, these tumors resemble hindgut NETs. These tumors show consistent expression of glucagon, pancreatic polypeptide, PYY, and the transcription factor SATB2, as well as generic neuroendocrine markers and keratins. The same L cell markers are expressed by cells within the normal middle ear epithelium. These markers define a valuable immunohistochemical profile that can be used for differential diagnosis of middle ear neoplasms, particularly in distinguishing epithelial NETs from paragangliomas. The discovery of neuroendocrine cells expressing the same markers in non-neoplastic middle ear mucosa opens new areas of investigation into the physiology of the normal middle ear and the pathophysiology of middle ear disorders.",

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AU - Tischler, Arthur S.

AU - Qamar, Adnan

AU - Deng, Fang Ming

AU - Perez-Ordonez, Bayardo

AU - Weinreb, Ilan

AU - Bishop, Justin A.

AU - Wenig, Bruce M.

AU - Mete, Ozgur

PY - 2021/12

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N2 - This morphological and immunohistochemical study demonstrates that tumors currently known as “middle ear adenomas” are truly well-differentiated epithelial neuroendocrine tumors (NETs) composed of cells comparable to normal intestinal L cells, and therefore, these tumors resemble hindgut NETs. These tumors show consistent expression of glucagon, pancreatic polypeptide, PYY, and the transcription factor SATB2, as well as generic neuroendocrine markers and keratins. The same L cell markers are expressed by cells within the normal middle ear epithelium. These markers define a valuable immunohistochemical profile that can be used for differential diagnosis of middle ear neoplasms, particularly in distinguishing epithelial NETs from paragangliomas. The discovery of neuroendocrine cells expressing the same markers in non-neoplastic middle ear mucosa opens new areas of investigation into the physiology of the normal middle ear and the pathophysiology of middle ear disorders.

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KW - L cell

KW - Middle ear adenoma

KW - Neuroendocrine tumor

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Middle Ear “Adenoma”: a Neuroendocrine Tumor with Predominant L Cell Differentiation

Abstract

Keywords

ASJC Scopus subject areas

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