Middle interhemispheric variant of holoprosencephaly associated with diffuse polymicrogyria

Jun ichi Takanashi, A. James Barkovich, Nancy J. Clegg, Mauricio R. Delgado

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

An 11-month-old boy was discovered to have a cleft palate, club foot, hypospadias, and myoclonic seizures. No in utero exposure to teratogens was identified. Brain MR imaging revealed a middle interhemispheric fusion variant of holoprosencephaly, diffuse polymicrogyria, and a hypoplastic brain stem; this was a distinctly unusual association of findings. We hypothesize that an unknown genetic factor causes disturbances of cleavage of the prosencephalon as well as neuronal migration and organization.

Original languageEnglish (US)
Pages (from-to)394-397
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume24
Issue number3
StatePublished - Mar 1 2003

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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