An 11-month-old boy was discovered to have a cleft palate, club foot, hypospadias, and myoclonic seizures. No in utero exposure to teratogens was identified. Brain MR imaging revealed a middle interhemispheric fusion variant of holoprosencephaly, diffuse polymicrogyria, and a hypoplastic brain stem; this was a distinctly unusual association of findings. We hypothesize that an unknown genetic factor causes disturbances of cleavage of the prosencephalon as well as neuronal migration and organization.
|Original language||English (US)|
|Number of pages||4|
|Journal||American Journal of Neuroradiology|
|State||Published - Mar 1 2003|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology