Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age infants

Catherine Y. Spong, David M. Scherer, Alessandro Ghidini, John C. Pezzullo, Carolyn M. Salafia, Gary S. Eglinton

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Problem: To evaluate the independent ability of midtrimester amniotic fluid tumor necrosis factor-alpha (TNF-α) in the prediction of small-for-gestational-age (SGA) infants. Method of study: In this case-control study, patients delivering a SGA infant were matched with controls based on GA at delivery, maternal age, race, and parity. Patients with immune disease, chronic hypertension, diabetes, asthma, congenital hearts disease, multiple gestation, and fetal anomalies were excluded. Amniotic fluid samples were immunoassayed for TNF-α. Potential confounding variables evaluated were maternal serum alpha-fetoprotein level, smoking history, pregnancy induced hypertension, and neonatal gender. Statistical analysis included Fisher's exact test and ANOVA after log transformation with P < 0.05 considered significant. Results: Eighteen patients delivered SGA neonates and were matched with 41 controls. No significant differences were identified in the confounding variables between patients with SGA neonates and controls. Amniotic fluid TNF-α. levels were not significantly different between patients subsequently delivering SGA neonates and controls [median 7.63 (range 0.25-16.1) pg/mL versus 9.39 (0.25-66.9) pg/mL, P = 0.8]. Conclusions: Midtrimester amniotic fluid TNF-α levels are not predictive of SGA neonates when compared with controls matched for gestational age at delivery.

Original languageEnglish (US)
Pages (from-to)236-239
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Volume37
Issue number3
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Small for Gestational Age Infant
Second Pregnancy Trimester
Amniotic Fluid
Gestational Age
Tumor Necrosis Factor-alpha
Newborn Infant
Confounding Factors (Epidemiology)
Pregnancy Induced Hypertension
Aptitude
Immune System Diseases
Maternal Age
alpha-Fetoproteins
Parity
Case-Control Studies
Heart Diseases
Analysis of Variance
Asthma
Smoking
History
Mothers

Keywords

  • Amniotic fluid
  • Small-for-gestational-age
  • TNF-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age infants. / Spong, Catherine Y.; Scherer, David M.; Ghidini, Alessandro; Pezzullo, John C.; Salafia, Carolyn M.; Eglinton, Gary S.

In: American Journal of Reproductive Immunology, Vol. 37, No. 3, 01.01.1997, p. 236-239.

Research output: Contribution to journalArticle

Spong, Catherine Y. ; Scherer, David M. ; Ghidini, Alessandro ; Pezzullo, John C. ; Salafia, Carolyn M. ; Eglinton, Gary S. / Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age infants. In: American Journal of Reproductive Immunology. 1997 ; Vol. 37, No. 3. pp. 236-239.
@article{a89085ab2a384bdc9b468fa8b03487dd,
title = "Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age infants",
abstract = "Problem: To evaluate the independent ability of midtrimester amniotic fluid tumor necrosis factor-alpha (TNF-α) in the prediction of small-for-gestational-age (SGA) infants. Method of study: In this case-control study, patients delivering a SGA infant were matched with controls based on GA at delivery, maternal age, race, and parity. Patients with immune disease, chronic hypertension, diabetes, asthma, congenital hearts disease, multiple gestation, and fetal anomalies were excluded. Amniotic fluid samples were immunoassayed for TNF-α. Potential confounding variables evaluated were maternal serum alpha-fetoprotein level, smoking history, pregnancy induced hypertension, and neonatal gender. Statistical analysis included Fisher's exact test and ANOVA after log transformation with P < 0.05 considered significant. Results: Eighteen patients delivered SGA neonates and were matched with 41 controls. No significant differences were identified in the confounding variables between patients with SGA neonates and controls. Amniotic fluid TNF-α. levels were not significantly different between patients subsequently delivering SGA neonates and controls [median 7.63 (range 0.25-16.1) pg/mL versus 9.39 (0.25-66.9) pg/mL, P = 0.8]. Conclusions: Midtrimester amniotic fluid TNF-α levels are not predictive of SGA neonates when compared with controls matched for gestational age at delivery.",
keywords = "Amniotic fluid, Small-for-gestational-age, TNF-α",
author = "Spong, {Catherine Y.} and Scherer, {David M.} and Alessandro Ghidini and Pezzullo, {John C.} and Salafia, {Carolyn M.} and Eglinton, {Gary S.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1111/j.1600-0897.1997.tb00221.x",
language = "English (US)",
volume = "37",
pages = "236--239",
journal = "American Journal of Reproductive Immunology",
issn = "8755-8920",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Midtrimester amniotic fluid tumor necrosis factor-alpha does not predict small-for-gestational-age infants

AU - Spong, Catherine Y.

AU - Scherer, David M.

AU - Ghidini, Alessandro

AU - Pezzullo, John C.

AU - Salafia, Carolyn M.

AU - Eglinton, Gary S.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Problem: To evaluate the independent ability of midtrimester amniotic fluid tumor necrosis factor-alpha (TNF-α) in the prediction of small-for-gestational-age (SGA) infants. Method of study: In this case-control study, patients delivering a SGA infant were matched with controls based on GA at delivery, maternal age, race, and parity. Patients with immune disease, chronic hypertension, diabetes, asthma, congenital hearts disease, multiple gestation, and fetal anomalies were excluded. Amniotic fluid samples were immunoassayed for TNF-α. Potential confounding variables evaluated were maternal serum alpha-fetoprotein level, smoking history, pregnancy induced hypertension, and neonatal gender. Statistical analysis included Fisher's exact test and ANOVA after log transformation with P < 0.05 considered significant. Results: Eighteen patients delivered SGA neonates and were matched with 41 controls. No significant differences were identified in the confounding variables between patients with SGA neonates and controls. Amniotic fluid TNF-α. levels were not significantly different between patients subsequently delivering SGA neonates and controls [median 7.63 (range 0.25-16.1) pg/mL versus 9.39 (0.25-66.9) pg/mL, P = 0.8]. Conclusions: Midtrimester amniotic fluid TNF-α levels are not predictive of SGA neonates when compared with controls matched for gestational age at delivery.

AB - Problem: To evaluate the independent ability of midtrimester amniotic fluid tumor necrosis factor-alpha (TNF-α) in the prediction of small-for-gestational-age (SGA) infants. Method of study: In this case-control study, patients delivering a SGA infant were matched with controls based on GA at delivery, maternal age, race, and parity. Patients with immune disease, chronic hypertension, diabetes, asthma, congenital hearts disease, multiple gestation, and fetal anomalies were excluded. Amniotic fluid samples were immunoassayed for TNF-α. Potential confounding variables evaluated were maternal serum alpha-fetoprotein level, smoking history, pregnancy induced hypertension, and neonatal gender. Statistical analysis included Fisher's exact test and ANOVA after log transformation with P < 0.05 considered significant. Results: Eighteen patients delivered SGA neonates and were matched with 41 controls. No significant differences were identified in the confounding variables between patients with SGA neonates and controls. Amniotic fluid TNF-α. levels were not significantly different between patients subsequently delivering SGA neonates and controls [median 7.63 (range 0.25-16.1) pg/mL versus 9.39 (0.25-66.9) pg/mL, P = 0.8]. Conclusions: Midtrimester amniotic fluid TNF-α levels are not predictive of SGA neonates when compared with controls matched for gestational age at delivery.

KW - Amniotic fluid

KW - Small-for-gestational-age

KW - TNF-α

UR - http://www.scopus.com/inward/record.url?scp=0030945424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030945424&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0897.1997.tb00221.x

DO - 10.1111/j.1600-0897.1997.tb00221.x

M3 - Article

C2 - 9127645

AN - SCOPUS:0030945424

VL - 37

SP - 236

EP - 239

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

SN - 8755-8920

IS - 3

ER -