Mighty Piwis Defend the Germline against Genome Intruders

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi) effector proteins that are associated with a recently discovered group of small RNAs (piRNAs). Recent studies in Drosophila and zebrafish directly implicate Piwi proteins in piRNA biogenesis to maintain transposon silencing in the germline genome (Brennecke et al., 2007; Gunawardane et al., 2007; Houwing et al., 2007). This function may be conserved in mice as loss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with increased transposon activity (Carmell et al., 2007).

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalCell
Volume129
Issue number1
DOIs
StatePublished - Apr 6 2007

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Genes
Genome
RNA
Zebrafish
RNA Interference
Stem cells
Small Interfering RNA
Drosophila
Proteins
Stem Cells
Defects

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Mighty Piwis Defend the Germline against Genome Intruders. / O'Donnell-Mendell, Kathryn A; Boeke, Jef D.

In: Cell, Vol. 129, No. 1, 06.04.2007, p. 37-44.

Research output: Contribution to journalArticle

O'Donnell-Mendell, Kathryn A ; Boeke, Jef D. / Mighty Piwis Defend the Germline against Genome Intruders. In: Cell. 2007 ; Vol. 129, No. 1. pp. 37-44.
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