TY - JOUR
T1 - Mighty Piwis Defend the Germline against Genome Intruders
AU - O'Donnell-Mendell, Kathryn A
AU - Boeke, Jef D.
PY - 2007/4/6
Y1 - 2007/4/6
N2 - Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi) effector proteins that are associated with a recently discovered group of small RNAs (piRNAs). Recent studies in Drosophila and zebrafish directly implicate Piwi proteins in piRNA biogenesis to maintain transposon silencing in the germline genome (Brennecke et al., 2007; Gunawardane et al., 2007; Houwing et al., 2007). This function may be conserved in mice as loss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with increased transposon activity (Carmell et al., 2007).
AB - Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi) effector proteins that are associated with a recently discovered group of small RNAs (piRNAs). Recent studies in Drosophila and zebrafish directly implicate Piwi proteins in piRNA biogenesis to maintain transposon silencing in the germline genome (Brennecke et al., 2007; Gunawardane et al., 2007; Houwing et al., 2007). This function may be conserved in mice as loss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with increased transposon activity (Carmell et al., 2007).
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U2 - 10.1016/j.cell.2007.03.028
DO - 10.1016/j.cell.2007.03.028
M3 - Review article
C2 - 17418784
AN - SCOPUS:33947731008
SN - 0092-8674
VL - 129
SP - 37
EP - 44
JO - Cell
JF - Cell
IS - 1
ER -