Mighty Piwis Defend the Germline against Genome Intruders

Research output: Contribution to journalReview article

198 Scopus citations

Abstract

Piwis are a germline-specific subclass of the Argonaute family of RNA interference (RNAi) effector proteins that are associated with a recently discovered group of small RNAs (piRNAs). Recent studies in Drosophila and zebrafish directly implicate Piwi proteins in piRNA biogenesis to maintain transposon silencing in the germline genome (Brennecke et al., 2007; Gunawardane et al., 2007; Houwing et al., 2007). This function may be conserved in mice as loss of Miwi2, a mouse Piwi homolog, leads to germline stem cell and meiotic defects correlated with increased transposon activity (Carmell et al., 2007).

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalCell
Volume129
Issue number1
DOIs
StatePublished - Apr 6 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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