Mild cognitive impairment: Cognitive screening or neuropsychological assessment?

Breno Satler De Oliveira Diniz, Paula Villela Nunes, Monica S. Yassuda, Fernanda S. Pereira, Mariana K. Flaks, Luciane F. Viola, Marcia Radanovic, Izabella Dutra De Abreu, Danilo T. Borelli, Wagner F. Gattaz, Orestes Vicente Forlenza

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Objective: To describe the neuropsychological profile of mild cognitive impairment subtypes (amnestic, non-amnestic and multiple-domain) of a clinical sample. We further address the diagnostic properties of the Mini-Mental State Examination and the Cambridge Cognitive Examination for the identification of the different mild cognitive impairment subtypes in clinical practice. Method: Cross-sectional clinical and neuropsychological evaluation of 249 elderly patients attending a memory clinic at a university hospital in Sao Paulo, Brazil. Results: The performance of patients with mild cognitive impairment was heterogeneous across the different subtests of the neuropsychological battery, with a trend towards an overall worse performance for amnestic (particularly multiple domain) mild cognitive impairment as compared to non-amnestic subtypes. Screening tests for dementia (Mini-Mental State Examination and Cambridge Cognitive Examination) adequately discriminated cases of mild Alzheimer's disease from controls, but they were not accurate to discriminate patients with mild cognitive impairment (all subtypes) from control subjects. Conclusions: The discrimination of mild cognitive impairment subtypes was possible only with the aid of a comprehensive neuropsychological assessment. It is necessary to develop new strategies for mild cognitive impairment screening in clinical practice.

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalRevista Brasileira de Psiquiatria
Issue number4
StatePublished - Dec 2008


  • Alzheimer disease
  • Cognition disorder
  • Dementia
  • Diagnosis
  • Neuropsychological tests

ASJC Scopus subject areas

  • Psychiatry and Mental health


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