Mild gestational diabetes mellitus and long-term child health

Mark B. Landon, Madeline Murguia Rice, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, Joseph R. Biggio, John M. Thorp, Edward K. Chien, George Saade, Alan M. Peaceman, Sean C. Blackwell, J. Peter VanDorsten

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE To evaluate whether treatment of mild gestational diabetes mellitus (GDM) confers sustained offspring health benefits, including a lower frequency of obesity. RESEARCH DESIGN AND METHODS Follow-up study of children (ages 5-10) ofwomen enrolled in a multicenter trial of treatment versus no treatment of mild GDM. Height, weight, blood pressure, waist circumference, fasting glucose, fasting insulin, triglycerides, and HDL cholesterol were measured. RESULTS Five hundred of 905 eligible offspring (55%) were enrolled. Maternal baseline characteristics were similar between the follow-up treated and untreated groups. The frequencies of BMI ≥95th (20.8% and 22.9%) and 85th (32.6% and 38.6%) percentiles were not significantly different in treated versus untreated offspring (P = 0.69 and P = 0.26). No associations were observed for BMI z score, logwaist circumference, log triglycerides, HDL cholesterol, blood pressure, or log HOMA-estimated insulin resistance (HOMA-IR). The effect of treatment was different by sex for fasting glucose and log HOMA-IR (P for interaction = 0.002 and 0.02, respectively) but not by age-group (5-6 and 7-10 years) for any outcomes. Female offspring of treated women had significantly lower fasting glucose levels. CONCLUSIONS Although treatment for mild GDM has been associated with neonatal benefits, no reduction in childhood obesity ormetabolic dysfunction in the offspring of treated women was found. However, only female of fspring of women treated for mild GDM had lower fasting glucose.

Original languageEnglish (US)
Pages (from-to)445-452
Number of pages8
JournalDiabetes Care
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2015

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Gestational Diabetes
Fasting
Glucose
HDL Cholesterol
Insulin Resistance
Triglycerides
Blood Pressure
Therapeutics
Pediatric Obesity
Waist Circumference
Insurance Benefits
Multicenter Studies
Age Groups
Obesity
Mothers
Child Health
Insulin
Weights and Measures

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Landon, M. B., Rice, M. M., Varner, M. W., Casey, B. M., Reddy, U. M., Wapner, R. J., ... VanDorsten, J. P. (2015). Mild gestational diabetes mellitus and long-term child health. Diabetes Care, 38(3), 445-452. https://doi.org/10.2337/dc14-2159

Mild gestational diabetes mellitus and long-term child health. / Landon, Mark B.; Rice, Madeline Murguia; Varner, Michael W.; Casey, Brian M.; Reddy, Uma M.; Wapner, Ronald J.; Rouse, Dwight J.; Biggio, Joseph R.; Thorp, John M.; Chien, Edward K.; Saade, George; Peaceman, Alan M.; Blackwell, Sean C.; VanDorsten, J. Peter.

In: Diabetes Care, Vol. 38, No. 3, 01.03.2015, p. 445-452.

Research output: Contribution to journalArticle

Landon, MB, Rice, MM, Varner, MW, Casey, BM, Reddy, UM, Wapner, RJ, Rouse, DJ, Biggio, JR, Thorp, JM, Chien, EK, Saade, G, Peaceman, AM, Blackwell, SC & VanDorsten, JP 2015, 'Mild gestational diabetes mellitus and long-term child health', Diabetes Care, vol. 38, no. 3, pp. 445-452. https://doi.org/10.2337/dc14-2159
Landon MB, Rice MM, Varner MW, Casey BM, Reddy UM, Wapner RJ et al. Mild gestational diabetes mellitus and long-term child health. Diabetes Care. 2015 Mar 1;38(3):445-452. https://doi.org/10.2337/dc14-2159
Landon, Mark B. ; Rice, Madeline Murguia ; Varner, Michael W. ; Casey, Brian M. ; Reddy, Uma M. ; Wapner, Ronald J. ; Rouse, Dwight J. ; Biggio, Joseph R. ; Thorp, John M. ; Chien, Edward K. ; Saade, George ; Peaceman, Alan M. ; Blackwell, Sean C. ; VanDorsten, J. Peter. / Mild gestational diabetes mellitus and long-term child health. In: Diabetes Care. 2015 ; Vol. 38, No. 3. pp. 445-452.
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abstract = "OBJECTIVE To evaluate whether treatment of mild gestational diabetes mellitus (GDM) confers sustained offspring health benefits, including a lower frequency of obesity. RESEARCH DESIGN AND METHODS Follow-up study of children (ages 5-10) ofwomen enrolled in a multicenter trial of treatment versus no treatment of mild GDM. Height, weight, blood pressure, waist circumference, fasting glucose, fasting insulin, triglycerides, and HDL cholesterol were measured. RESULTS Five hundred of 905 eligible offspring (55{\%}) were enrolled. Maternal baseline characteristics were similar between the follow-up treated and untreated groups. The frequencies of BMI ≥95th (20.8{\%} and 22.9{\%}) and 85th (32.6{\%} and 38.6{\%}) percentiles were not significantly different in treated versus untreated offspring (P = 0.69 and P = 0.26). No associations were observed for BMI z score, logwaist circumference, log triglycerides, HDL cholesterol, blood pressure, or log HOMA-estimated insulin resistance (HOMA-IR). The effect of treatment was different by sex for fasting glucose and log HOMA-IR (P for interaction = 0.002 and 0.02, respectively) but not by age-group (5-6 and 7-10 years) for any outcomes. Female offspring of treated women had significantly lower fasting glucose levels. CONCLUSIONS Although treatment for mild GDM has been associated with neonatal benefits, no reduction in childhood obesity ormetabolic dysfunction in the offspring of treated women was found. However, only female of fspring of women treated for mild GDM had lower fasting glucose.",
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N2 - OBJECTIVE To evaluate whether treatment of mild gestational diabetes mellitus (GDM) confers sustained offspring health benefits, including a lower frequency of obesity. RESEARCH DESIGN AND METHODS Follow-up study of children (ages 5-10) ofwomen enrolled in a multicenter trial of treatment versus no treatment of mild GDM. Height, weight, blood pressure, waist circumference, fasting glucose, fasting insulin, triglycerides, and HDL cholesterol were measured. RESULTS Five hundred of 905 eligible offspring (55%) were enrolled. Maternal baseline characteristics were similar between the follow-up treated and untreated groups. The frequencies of BMI ≥95th (20.8% and 22.9%) and 85th (32.6% and 38.6%) percentiles were not significantly different in treated versus untreated offspring (P = 0.69 and P = 0.26). No associations were observed for BMI z score, logwaist circumference, log triglycerides, HDL cholesterol, blood pressure, or log HOMA-estimated insulin resistance (HOMA-IR). The effect of treatment was different by sex for fasting glucose and log HOMA-IR (P for interaction = 0.002 and 0.02, respectively) but not by age-group (5-6 and 7-10 years) for any outcomes. Female offspring of treated women had significantly lower fasting glucose levels. CONCLUSIONS Although treatment for mild GDM has been associated with neonatal benefits, no reduction in childhood obesity ormetabolic dysfunction in the offspring of treated women was found. However, only female of fspring of women treated for mild GDM had lower fasting glucose.

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