Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders

Elan D. Louis, Ming X. Tang, Nicole Schupf

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

There is some evidence that mild parkinsonian signs (MPSs) are associated with increased risk of dementia, suggesting that MPS could be an early biomarker for dementia. Our aims, in a new cohort, were to determine whether (1) baseline MPS are a predictor of incident dementia and (2) there is an interaction between MPS and other baseline risk factors for dementia (i.e., the presence of both together greatly elevates the risk of dementia) was the objective. In a prospective, longitudinal study of community-dwelling elders in northern Manhattan, NY, Parkinsonian signs were rated with an abbreviated Unified Parkinson's Disease Rating Scale. Risk of incident dementia was assessed using Cox proportional hazards models. There were 1,851 participants (mean follow-up 5 3.7 years). Participants with baseline MPS were twice as likely to develop dementia as participants without MPS: 16.3% versus 7.7%, unadjusted hazards ratio (HR) 5 2.24 (P < 0.001), adjusted HR 5 1.98 (P < 0.001). MPS were divided into three subtypes: adjusted HRaxial dys-function = 2.45 (P < 0.001), adjusted HRtremor = 2.38 (P = 0.006), and adjusted HRrigidity = 1.16 (P = 0.58). When MPS were treated as a continuous variable, the adjusted HR = 1.15 (P = 0.001). There were no interactions between MPS and other baseline risk factors for dementia, including gender, education, race, family history of dementia, stroke, and apolipoprotein E-e4. Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalMovement Disorders
Volume25
Issue number2
DOIs
StatePublished - Jan 30 2010

Keywords

  • Alzheimer's disease
  • Elderly
  • Epidemiology
  • Incident dementia
  • Mild parkinsonian signs
  • Population

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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