Mild-to-moderate obesity: Implications for respiratory mechanics at rest and during exercise in young men

D. S. DeLorey, B. L. Wyrick, T. G. Babb

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the effect of mild-to-moderate obesity on respiratory mechanics at rest and during exercise in obese men. We hypothesized that the simple mass loading of obesity would alter both end-expiratory lung volume (EELV) and respiratory pressures (gastric, Pga and transpulmonary, PTP) in resting body positions and during graded cycle ergometry to exhaustion. SUBJECTS: A total of 10 obese (38±5% body fat; mean ±s.d.) and nine lean (18±4%) men were studied. METHODS: Body composition (by body circumferences and hydrostatic weighing) and pulmonary function were measured at rest. Breathing mechanics were measured at rest in the upright-seated position, supine, and during cycling exercise. Data were analyzed by independent t-test. RESULTS: EELV was significantly lower in the obese men in the supine (30±4 vs 37±6% total lung capacity (TLC)) and seated (39±6 vs 47±5%TLC) positions and at ventilatory threshold (35±5 vs 45±7%TLC) (P<0.01). In contrast, at peak exercise, EELV was not different between groups. Respiratory pressures (P ga and PTP) were elevated (P<0.05) during one or more phases of the breathing cycle at rest and during exercise in obese men. CONCLUSION: These data demonstrate that mild-to-moderate obesity in young men results in reduced lung volumes and alterations in respiratory mechanics when supine, seated at rest, and during exercise. During moderate exercise, obesity does not appear to limit changes in EELV; however, the regulation of EELV during heavy exercise appears to be affected.

Original languageEnglish (US)
Pages (from-to)1039-1047
Number of pages9
JournalInternational Journal of Obesity
Volume29
Issue number9
DOIs
StatePublished - Sep 2005

Fingerprint

Respiratory Mechanics
mechanics
exercise
obesity
Obesity
lungs
Exercise
Lung
Total Lung Capacity
breathing
Pressure
Ergometry
Body Composition
Posture
lung function
Adipose Tissue
Stomach
Respiration
body fat
body composition

Keywords

  • Control of breathing
  • Exercise
  • Lung volumes
  • Pulmonary function
  • Ventilation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Mild-to-moderate obesity : Implications for respiratory mechanics at rest and during exercise in young men. / DeLorey, D. S.; Wyrick, B. L.; Babb, T. G.

In: International Journal of Obesity, Vol. 29, No. 9, 09.2005, p. 1039-1047.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To investigate the effect of mild-to-moderate obesity on respiratory mechanics at rest and during exercise in obese men. We hypothesized that the simple mass loading of obesity would alter both end-expiratory lung volume (EELV) and respiratory pressures (gastric, Pga and transpulmonary, PTP) in resting body positions and during graded cycle ergometry to exhaustion. SUBJECTS: A total of 10 obese (38±5{\%} body fat; mean ±s.d.) and nine lean (18±4{\%}) men were studied. METHODS: Body composition (by body circumferences and hydrostatic weighing) and pulmonary function were measured at rest. Breathing mechanics were measured at rest in the upright-seated position, supine, and during cycling exercise. Data were analyzed by independent t-test. RESULTS: EELV was significantly lower in the obese men in the supine (30±4 vs 37±6{\%} total lung capacity (TLC)) and seated (39±6 vs 47±5{\%}TLC) positions and at ventilatory threshold (35±5 vs 45±7{\%}TLC) (P<0.01). In contrast, at peak exercise, EELV was not different between groups. Respiratory pressures (P ga and PTP) were elevated (P<0.05) during one or more phases of the breathing cycle at rest and during exercise in obese men. CONCLUSION: These data demonstrate that mild-to-moderate obesity in young men results in reduced lung volumes and alterations in respiratory mechanics when supine, seated at rest, and during exercise. During moderate exercise, obesity does not appear to limit changes in EELV; however, the regulation of EELV during heavy exercise appears to be affected.",
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N2 - OBJECTIVE: To investigate the effect of mild-to-moderate obesity on respiratory mechanics at rest and during exercise in obese men. We hypothesized that the simple mass loading of obesity would alter both end-expiratory lung volume (EELV) and respiratory pressures (gastric, Pga and transpulmonary, PTP) in resting body positions and during graded cycle ergometry to exhaustion. SUBJECTS: A total of 10 obese (38±5% body fat; mean ±s.d.) and nine lean (18±4%) men were studied. METHODS: Body composition (by body circumferences and hydrostatic weighing) and pulmonary function were measured at rest. Breathing mechanics were measured at rest in the upright-seated position, supine, and during cycling exercise. Data were analyzed by independent t-test. RESULTS: EELV was significantly lower in the obese men in the supine (30±4 vs 37±6% total lung capacity (TLC)) and seated (39±6 vs 47±5%TLC) positions and at ventilatory threshold (35±5 vs 45±7%TLC) (P<0.01). In contrast, at peak exercise, EELV was not different between groups. Respiratory pressures (P ga and PTP) were elevated (P<0.05) during one or more phases of the breathing cycle at rest and during exercise in obese men. CONCLUSION: These data demonstrate that mild-to-moderate obesity in young men results in reduced lung volumes and alterations in respiratory mechanics when supine, seated at rest, and during exercise. During moderate exercise, obesity does not appear to limit changes in EELV; however, the regulation of EELV during heavy exercise appears to be affected.

AB - OBJECTIVE: To investigate the effect of mild-to-moderate obesity on respiratory mechanics at rest and during exercise in obese men. We hypothesized that the simple mass loading of obesity would alter both end-expiratory lung volume (EELV) and respiratory pressures (gastric, Pga and transpulmonary, PTP) in resting body positions and during graded cycle ergometry to exhaustion. SUBJECTS: A total of 10 obese (38±5% body fat; mean ±s.d.) and nine lean (18±4%) men were studied. METHODS: Body composition (by body circumferences and hydrostatic weighing) and pulmonary function were measured at rest. Breathing mechanics were measured at rest in the upright-seated position, supine, and during cycling exercise. Data were analyzed by independent t-test. RESULTS: EELV was significantly lower in the obese men in the supine (30±4 vs 37±6% total lung capacity (TLC)) and seated (39±6 vs 47±5%TLC) positions and at ventilatory threshold (35±5 vs 45±7%TLC) (P<0.01). In contrast, at peak exercise, EELV was not different between groups. Respiratory pressures (P ga and PTP) were elevated (P<0.05) during one or more phases of the breathing cycle at rest and during exercise in obese men. CONCLUSION: These data demonstrate that mild-to-moderate obesity in young men results in reduced lung volumes and alterations in respiratory mechanics when supine, seated at rest, and during exercise. During moderate exercise, obesity does not appear to limit changes in EELV; however, the regulation of EELV during heavy exercise appears to be affected.

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