Mild Traumatic Brain Injury Is Related to Elevated Cerebrospinal Fluid Tau in Alzheimer's Disease Dementia

Christian Lobue, Brendan J. Kelley, John Hart, Jessica Helphrey, Jeff Schaffert, C. Munro Cullum, Matthew E. Peters, Peter M. Douglas

Research output: Contribution to journalArticlepeer-review

Abstract

Few studies have examined an association between mild traumatic brain injury (mTBI) and Alzheimer's disease (AD). For this reason, we compared an AD dementia group with an mTBI history (n = 10) to a matched AD control group (n = 20) on measures of cognitive function, cerebral glucose metabolism, and markers of amyloid and tau deposition. Only a trend and medium-to-large effect size for higher phosphorylated and total tau was identified for the mTBI group. A history of mTBI may be associated with greater tau in AD, indicating a potential pathway for increasing risk for AD, though further evaluation with larger samples is needed.

Original languageEnglish (US)
Pages (from-to)1491-1496
Number of pages6
JournalJournal of Alzheimer's Disease
Volume87
Issue number4
DOIs
StatePublished - 2022

Keywords

  • Biomarkers
  • concussion
  • dementia
  • neurodegeneration
  • risk factor
  • tau formation
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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