Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

Kelley A. Brix, David L. Brody, Jamie B. Grimes, Avraham Yitzhak, Denes Agoston, Matt Aldag, Regina Armstrong, Peethambaran Arun, Michel Audette, Debra Babcock, Carey Balaban, Rohan Banton, Patrick Bellgowan, David Borkholder, Steven Broglio, Elizabeth Brokaw, Robert Cantu, Walter Carr, Sandi Chapman, Joan CmarikBrian Colder, Jeff Colombe, David Cook, Tara Cozzarelli, Uade Olaghere Da Silva, Nitin Daphalapurkar, Bernard Dardzinski, Tom DeGraba, James DeMar, Douglas DeWitt, Dara Dickstein, Josh Duckworth, Gregory Elder, Reza Fazel-Rezai, Michael Fine, Gary Fiskum, Adam Fournier, Shaleish Ganpule, Jessica Gill, John F. Glenn, Colin Greene, Nigel Greig, Chad Haering, Jason Harrington, Amy Hein, Kathy Helmick, Ramona Hicks, Sidney Hinds, Stuart Hoffman, Iren Horkayne-Szakaly, Diego Iacono, Erick Ishii, Robert V. Jones, Ghodrat Karami, Daniel Krawczyk, Robert Labutta, Robert Latta, Theresa Lattimore, Michael Leggieri, Fabio Leonessa, Alexander Lin, Geoffrey Ling, Matt Long, Kun Ping Lu, Stephanie Maxfield Panker, Joseph McCabe, Andrew Merkle, Philip Montenigro, Gary P. Mueller, Laurel Ng, Savita Nigam, John O'Donnell, David Okonkwo, Ingrid Pauli, Daniel Perl, Elaine Peskind, Bryan Pfister, Mat Philippens, Thuvan Piehler, Julie Proctor, Andrzej Przekwas, Felicia Qashu, Murray Raskind, Alexander Razumovsky, Jaques Reifman, Patricio Reyes, Paul Rigby, Marten Risling, Meghan Robinson, Tyler Rooks, Charles Rosen, Gail Rosseau, Wendy Sammons-Jackson, Anthony Santago, Richard Shoge, Chandler Sours, James Stone, Mike Templin, Victoria Tepe, Peter Thielen, Mike Thomas, Thomas Timmes, Frank Tortella, Laura Tucker, David Tweedie, Dale Vander Hamm, B. Christie Vu, Ying Wang, Therese West, Elisabeth Wilde, Adam Willis, John Wu, Laila Zai, Nikki Zander, James Zheng, Mariusz Ziejewski

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The potential relationship between chronic traumatic encephalopathy (CTE) and head injuries such as blast-related traumatic brain injury (TBI) is an important area of study, particularly for military and contact sports populations, yet little is known about this relationship. To address this topic, the Department of Defense (DoD) Blast Injury Research Program Coordinating Office organized the 2015 International State-of-The-Science Meeting, which brought together subject matter experts from the DoD, other federal agencies, academia, industry, foreign allies, and the sports community. Over the course of the meeting, this community of experts reached a consensus regarding the current body of knowledge and the future of the field. The overarching finding was that there is insufficient existing scientific evidence to link blast-related TBI with CTE. The meeting's Expert Panel also agreed on 13 additional findings describing research and knowledge gaps, clinical gaps, and research opportunities that, if addressed with focused effort, would further the understanding of the relationship between blast-related TBI and CTE. To this end, the Expert Panel also developed six recommendations for advancing research, each with short-and long-Term goals. Among the six recommendations, the Expert Panel identified the first four as highest priority for addressing pressing research needs. These four high-priority recommendations include, in order of priority: (1) more collection and study of clinical neuropathology samples, (2) standardization of clinical diagnostic criteria, (3) development of clinically appropriate and standardized animal models, and (4) development of noninvasive serial assessment strategies (i.e., imaging or biospecimen biomarkers).

Original languageEnglish (US)
Pages (from-to)S18-S25
JournalJournal of neurotrauma
Volume34
Issue numberS1
DOIs
StatePublished - Sep 2017

Keywords

  • blast-related injury
  • chronic traumatic encephalopathy (CTE)
  • traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Brix, K. A., Brody, D. L., Grimes, J. B., Yitzhak, A., Agoston, D., Aldag, M., Armstrong, R., Arun, P., Audette, M., Babcock, D., Balaban, C., Banton, R., Bellgowan, P., Borkholder, D., Broglio, S., Brokaw, E., Cantu, R., Carr, W., Chapman, S., ... Ziejewski, M. (2017). Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations. Journal of neurotrauma, 34(S1), S18-S25. https://doi.org/10.1089/neu.2017.5222