Mimicking nature's nanocarrier: Synthetic low-density lipoprotein-like nanoparticles for cancer-drug delivery

Ian R. Corbin, Gang Zheng

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Low-density lipoproteins have long been recognized as a viable nanocarrier for targeted delivery of drug and imaging agents. Many groups have published promising initial findings; however, progress in this field has been impeded by the need to isolate low-density lipoproteins from fresh donor plasma. In a recent paper by Nikanjam and colleagues, synthetic low-density lipoprotein-like nanoparticles were prepared from commercial lipids and a bifunctional synthetic peptide containing the low-density lipoprotein receptor-binding domain and the lipid-binding motif. These particles were shown to behave similarly to native low-density lipoproteins and also to bind to the low-density lipoprotein receptor on cancer cells. Herein, we evaluate the utility of this novel delivery vehicle and discuss what role this technology may have in nanomedicine.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalNanomedicine
Volume2
Issue number3
DOIs
StatePublished - Jun 1 2007

Keywords

  • Apoprotein B-100
  • Cancer
  • Low-density lipoprotein
  • Low-density lipoprotein receptor
  • Nanocarrier
  • Peptide

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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