TY - JOUR
T1 - Mineralization dynamics of regenerate bone during mandibular osteodistraction
AU - Cope, Jason B.
AU - Samchukov, Mikhail L.
N1 - Funding Information:
The authors would like to thank Drs Alexander Cherkashin, Steven Smith, Larry Wolford, Pedro Franco, and Rena Talwar for their assistance with this project and Gerald Hill and Priscilla Gillaspie for animal care. The work herein was supported in part by grants from the AAOF, BCD Orthodontic Spe cial Fund, NIDCR (DE07256), CPCFA, ASAMI-NA, FOR, and TSRHC.
PY - 2001/6
Y1 - 2001/6
N2 - Distraction osteogenesis offers an alternative approach for the correction of craniofacial deformities, yet little substantive data is available regarding mineralization of the forming regenerate. The purpose of this study was to evaluate, by plain film radiography and digital subtraction radiography, the mineralization dynamics of regenerate bone during osteodistraction. Thirteen skeletally mature male beagle dogs underwent 10 mm of bilateral mandibular distraction osteogenesis, at which time the bone was allowed to consolidate for either 4, 6, or 8 weeks. The tissues were then evaluated clinically and radiographically. The results demonstrate that several different types of regenerate are evident during mineralization of the distraction gap. A classification system is presented based on the length, width, and density of the mineralizing regenerate, as well as the presence or absence of an interzone. It appears that important factors for determining regenerate stability are the presence or absence of an interzone, as well as the width of the regenerate relative to the host bone segments. Finally, in cases where an interzone is present, subtraction radiography may provide a means of evaluating the level of mineralization within the interzone as well as the dynamics of mineralization over the course of distraction and consolidation.
AB - Distraction osteogenesis offers an alternative approach for the correction of craniofacial deformities, yet little substantive data is available regarding mineralization of the forming regenerate. The purpose of this study was to evaluate, by plain film radiography and digital subtraction radiography, the mineralization dynamics of regenerate bone during osteodistraction. Thirteen skeletally mature male beagle dogs underwent 10 mm of bilateral mandibular distraction osteogenesis, at which time the bone was allowed to consolidate for either 4, 6, or 8 weeks. The tissues were then evaluated clinically and radiographically. The results demonstrate that several different types of regenerate are evident during mineralization of the distraction gap. A classification system is presented based on the length, width, and density of the mineralizing regenerate, as well as the presence or absence of an interzone. It appears that important factors for determining regenerate stability are the presence or absence of an interzone, as well as the width of the regenerate relative to the host bone segments. Finally, in cases where an interzone is present, subtraction radiography may provide a means of evaluating the level of mineralization within the interzone as well as the dynamics of mineralization over the course of distraction and consolidation.
KW - Distraction osteogenesis
KW - Mandible
KW - Mineralization
KW - Subtraction radiography
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U2 - 10.1054/ijom.2000.0044
DO - 10.1054/ijom.2000.0044
M3 - Article
C2 - 11420907
AN - SCOPUS:0035354511
SN - 0901-5027
VL - 30
SP - 234
EP - 242
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 3
ER -