Minimal change disease with acute renal failure: A case againts the nephrosarca hypothesis

Mary Ann Cameron, Usha Peri, Thomas E. Rogers, Orson W. Moe

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


An unusual but well-documented presentation of minimal change disease is nephrotic proteinuria and acute renal failure. One pathophysiological mechanism proposed to explain this syndrome is nephrosarca, or severe oedema of the kidney. We describe a patient with minimal change disease who presented with heavy proteinuria and acute renal failure but had no evidence of renal interstitial oedema on biopsy. Aggressive fluid removal did not reverse the acute renal failure. Renal function slowly returned concomitant with resolution of the nephrotic syndrome following corticosteroid therapy. The time profile of the clinical events is not compatible with the nephrosarca hypothesis and suggests an alternative pathophysiological model for the diminished glomerular filtration rate seen in some cases of minimal change disease.

Original languageEnglish (US)
Pages (from-to)2642-2646
Number of pages5
JournalNephrology Dialysis Transplantation
Issue number10
StatePublished - Oct 2004


  • Acute renal failure
  • Glomerular filtation rate
  • Minimal change disease
  • Nephrosarca proteinuria

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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