Minimally Invasive Approach for Resection of Parameningeal Rhabdomyosarcoma

Aileen Wertz, Brittny N. Tillman, Jennifer V. Brinkmeier, Tiffany A. Glazer, Andrew D. Kroeker, Steven E. Sullivan, Erin L. McKean

Research output: Contribution to journalArticle

Abstract

Background About one-third of rhabdomyosarcomas arise in the head and neck, with parameningeal primaries accounting for half of these. Principles of management involve chemotherapy, radiation, or both, in addition to surgical biopsy, debulking, and complete or near-complete resection. In the head and neck, diagnostic biopsies have historically been performed without attempt at resection due to proximity to critical structures and cosmetic considerations. Methods Retrospective chart review of three cases of rhabdomyosarcoma at the cranial base managed through minimally invasive endoscopic surgical resection and adjuvant therapy. Results Three patients were identified as having undergone endoscopic surgical debulking or margin-negative resection of a rhabdomyosarcoma of the cranial base. Two of three patients had complete resection based on intraoperative margin control. All three patients underwent adjuvant therapy within 1 month of diagnosis. Follow-up time ranged from 5 months to 3 years with all patients disease-free at last follow-up. Conclusion Skull base surgeons should routinely be involved in multidisciplinary treatment planning for parameningeal rhabdomyosarcomas, as surgical options have evolved to allow for potential endoscopic resection with low morbidity and no or minimal delay in additional treatment options.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalJournal of Neurological Surgery, Part B: Skull Base
Volume78
Issue number3
DOIs
StatePublished - Jun 1 2017

Keywords

  • endoscopic
  • minimally invasive
  • parameningeal
  • rhabdomyosarcoma

ASJC Scopus subject areas

  • Clinical Neurology

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    Wertz, A., Tillman, B. N., Brinkmeier, J. V., Glazer, T. A., Kroeker, A. D., Sullivan, S. E., & McKean, E. L. (2017). Minimally Invasive Approach for Resection of Parameningeal Rhabdomyosarcoma. Journal of Neurological Surgery, Part B: Skull Base, 78(3), 210-214. https://doi.org/10.1055/s-0036-1597279