TY - JOUR
T1 - Minimally invasive techniques for the treatment of liver tumors
AU - Leyendecker, J. R.
AU - Dodd, G. D.
PY - 2001
Y1 - 2001
N2 - Recently, several minimally invasive, image-guided therapies have been developed for the local treatment of hepatocellular carcinoma (HCC) and hepatic metastases in patients who are considered poor candidates for surgical resection. Radio-frequency ablation, microwave ablation, and laser ablation all destroy tumor by creating a hyperthermic injury. Cryoablation and ethanol ablation achieve cellular death through freezing and direct toxicity, respectively. Chemoembolization is unique in that the entire liver can be treated over time with a combination of cytotoxic drugs and embolic agents, potentially reducing the rate of recurrence from radiologically occult tumor. Outcomes for minimally invasive therapy have approached the success rate of surgical resection in some series with considerably fewer complications. However, a paucity of randomized trials and variability in reporting limit assessment of the relative role of these techniques in clinical practice. With a few exceptions, the indications, contraindications, and complications associated with the different techniques are similar, and success with HCC has exceeded that for metastatic disease independent of technique.
AB - Recently, several minimally invasive, image-guided therapies have been developed for the local treatment of hepatocellular carcinoma (HCC) and hepatic metastases in patients who are considered poor candidates for surgical resection. Radio-frequency ablation, microwave ablation, and laser ablation all destroy tumor by creating a hyperthermic injury. Cryoablation and ethanol ablation achieve cellular death through freezing and direct toxicity, respectively. Chemoembolization is unique in that the entire liver can be treated over time with a combination of cytotoxic drugs and embolic agents, potentially reducing the rate of recurrence from radiologically occult tumor. Outcomes for minimally invasive therapy have approached the success rate of surgical resection in some series with considerably fewer complications. However, a paucity of randomized trials and variability in reporting limit assessment of the relative role of these techniques in clinical practice. With a few exceptions, the indications, contraindications, and complications associated with the different techniques are similar, and success with HCC has exceeded that for metastatic disease independent of technique.
KW - Hepatic metastases
KW - Hepatocellular carcinoma
KW - Image-guided ablation
UR - http://www.scopus.com/inward/record.url?scp=0034970705&partnerID=8YFLogxK
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U2 - 10.1055/s-2001-15345
DO - 10.1055/s-2001-15345
M3 - Article
C2 - 11436578
AN - SCOPUS:0034970705
SN - 0272-8087
VL - 21
SP - 283
EP - 291
JO - Seminars in liver disease
JF - Seminars in liver disease
IS - 2
ER -