Minireview

Familiar faces in unfamiliar places: The emerging role of nuclear receptors in lung cancer

Paul Yenerall, Ralf Kittler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nuclear hormone receptors (NRs) are a superfamily of 48 transcription factors that are frequently modulated by ligands and control various cancer-relevant cellular pathways, such as differentiation, proliferation, migration, and metabolism. These properties make them excellent therapeutic targets in cancers dependent upon their activity, and as such, 3 NRs, estrogen receptor-α, androgen receptor, and retinoic acid receptor-α (more specifically, the promyelocytic leukemia-retinoic acid receptor-α translocation), have been targeted clinically in breast cancer, prostate cancer, and acute promyelocytic leukemia, respectively. Recently, a number of studies have highlighted a putative role for NRs in nonsmall cell lung cancer (NSCLC), a highly lethal type of lung cancer with relatively few targeted agents. Here, we review the potential roles of selected NRs in NSCLC and offer insights on how NRs may be leveraged in NSCLC to improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)1675-1683
Number of pages9
JournalMolecular Endocrinology
Volume29
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Cytoplasmic and Nuclear Receptors
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Retinoic Acid Receptors
Prostatic Neoplasms
Acute Promyelocytic Leukemia
Androgen Receptors
Estrogen Receptors
Neoplasms
Leukemia
Transcription Factors
Breast Neoplasms
Ligands
Therapeutics

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

Minireview : Familiar faces in unfamiliar places: The emerging role of nuclear receptors in lung cancer. / Yenerall, Paul; Kittler, Ralf.

In: Molecular Endocrinology, Vol. 29, No. 12, 01.12.2015, p. 1675-1683.

Research output: Contribution to journalArticle

@article{105f04f7ba69481ebf1713f97e4b455f,
title = "Minireview: Familiar faces in unfamiliar places: The emerging role of nuclear receptors in lung cancer",
abstract = "Nuclear hormone receptors (NRs) are a superfamily of 48 transcription factors that are frequently modulated by ligands and control various cancer-relevant cellular pathways, such as differentiation, proliferation, migration, and metabolism. These properties make them excellent therapeutic targets in cancers dependent upon their activity, and as such, 3 NRs, estrogen receptor-α, androgen receptor, and retinoic acid receptor-α (more specifically, the promyelocytic leukemia-retinoic acid receptor-α translocation), have been targeted clinically in breast cancer, prostate cancer, and acute promyelocytic leukemia, respectively. Recently, a number of studies have highlighted a putative role for NRs in nonsmall cell lung cancer (NSCLC), a highly lethal type of lung cancer with relatively few targeted agents. Here, we review the potential roles of selected NRs in NSCLC and offer insights on how NRs may be leveraged in NSCLC to improve patient outcomes.",
author = "Paul Yenerall and Ralf Kittler",
year = "2015",
month = "12",
day = "1",
doi = "10.1210/me.2015-1199",
language = "English (US)",
volume = "29",
pages = "1675--1683",
journal = "Molecular Endocrinology",
issn = "0888-8809",
publisher = "The Endocrine Society",
number = "12",

}

TY - JOUR

T1 - Minireview

T2 - Familiar faces in unfamiliar places: The emerging role of nuclear receptors in lung cancer

AU - Yenerall, Paul

AU - Kittler, Ralf

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Nuclear hormone receptors (NRs) are a superfamily of 48 transcription factors that are frequently modulated by ligands and control various cancer-relevant cellular pathways, such as differentiation, proliferation, migration, and metabolism. These properties make them excellent therapeutic targets in cancers dependent upon their activity, and as such, 3 NRs, estrogen receptor-α, androgen receptor, and retinoic acid receptor-α (more specifically, the promyelocytic leukemia-retinoic acid receptor-α translocation), have been targeted clinically in breast cancer, prostate cancer, and acute promyelocytic leukemia, respectively. Recently, a number of studies have highlighted a putative role for NRs in nonsmall cell lung cancer (NSCLC), a highly lethal type of lung cancer with relatively few targeted agents. Here, we review the potential roles of selected NRs in NSCLC and offer insights on how NRs may be leveraged in NSCLC to improve patient outcomes.

AB - Nuclear hormone receptors (NRs) are a superfamily of 48 transcription factors that are frequently modulated by ligands and control various cancer-relevant cellular pathways, such as differentiation, proliferation, migration, and metabolism. These properties make them excellent therapeutic targets in cancers dependent upon their activity, and as such, 3 NRs, estrogen receptor-α, androgen receptor, and retinoic acid receptor-α (more specifically, the promyelocytic leukemia-retinoic acid receptor-α translocation), have been targeted clinically in breast cancer, prostate cancer, and acute promyelocytic leukemia, respectively. Recently, a number of studies have highlighted a putative role for NRs in nonsmall cell lung cancer (NSCLC), a highly lethal type of lung cancer with relatively few targeted agents. Here, we review the potential roles of selected NRs in NSCLC and offer insights on how NRs may be leveraged in NSCLC to improve patient outcomes.

UR - http://www.scopus.com/inward/record.url?scp=84948979247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948979247&partnerID=8YFLogxK

U2 - 10.1210/me.2015-1199

DO - 10.1210/me.2015-1199

M3 - Article

VL - 29

SP - 1675

EP - 1683

JO - Molecular Endocrinology

JF - Molecular Endocrinology

SN - 0888-8809

IS - 12

ER -