Minireview: From anorexia to obesity - The Yin and Yang of body weight control

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

Over the past decade, there has been a tremendous increase in the understanding of the molecular and neural mechanisms that control food intake and body weight. Yet eating disorders and cachexia are still common, and obesity cases are rising at alarming rates. Thus, despite recent progress, an increased understanding of the molecular and neural substrates that control body weight homeostasis is a major public health goal. In this review, we discuss the mechanisms by which metabolic signals interact with key behavioral, neuroendocrine, and autonomic regulatory regions of the central nervous system. Additionally, we offer a model in which hormones such as leptin and ghrelin interact with similar central nervous system circuits and engage them in such a way as to maintain an appropriate and tight regulation of body weight and food intake. Our model predicts that overstimulation or understimulation of these central pathways can result in obesity, anorexia, or cachexia.

Original languageEnglish (US)
Pages (from-to)3749-3756
Number of pages8
JournalEndocrinology
Volume144
Issue number9
DOIs
StatePublished - Sep 1 2003

Fingerprint

Yin-Yang
Anorexia
Cachexia
Obesity
Body Weight
Central Nervous System
Eating
Ghrelin
Nucleic Acid Regulatory Sequences
Leptin
Homeostasis
Public Health
Hormones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Minireview : From anorexia to obesity - The Yin and Yang of body weight control. / Zigman, Jeffrey M.; Elmquist, Joel K.

In: Endocrinology, Vol. 144, No. 9, 01.09.2003, p. 3749-3756.

Research output: Contribution to journalArticle

@article{a0d3da0749ff4a019cf2af634bb8e24d,
title = "Minireview: From anorexia to obesity - The Yin and Yang of body weight control",
abstract = "Over the past decade, there has been a tremendous increase in the understanding of the molecular and neural mechanisms that control food intake and body weight. Yet eating disorders and cachexia are still common, and obesity cases are rising at alarming rates. Thus, despite recent progress, an increased understanding of the molecular and neural substrates that control body weight homeostasis is a major public health goal. In this review, we discuss the mechanisms by which metabolic signals interact with key behavioral, neuroendocrine, and autonomic regulatory regions of the central nervous system. Additionally, we offer a model in which hormones such as leptin and ghrelin interact with similar central nervous system circuits and engage them in such a way as to maintain an appropriate and tight regulation of body weight and food intake. Our model predicts that overstimulation or understimulation of these central pathways can result in obesity, anorexia, or cachexia.",
author = "Zigman, {Jeffrey M.} and Elmquist, {Joel K.}",
year = "2003",
month = "9",
day = "1",
doi = "10.1210/en.2003-0241",
language = "English (US)",
volume = "144",
pages = "3749--3756",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "9",

}

TY - JOUR

T1 - Minireview

T2 - From anorexia to obesity - The Yin and Yang of body weight control

AU - Zigman, Jeffrey M.

AU - Elmquist, Joel K.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Over the past decade, there has been a tremendous increase in the understanding of the molecular and neural mechanisms that control food intake and body weight. Yet eating disorders and cachexia are still common, and obesity cases are rising at alarming rates. Thus, despite recent progress, an increased understanding of the molecular and neural substrates that control body weight homeostasis is a major public health goal. In this review, we discuss the mechanisms by which metabolic signals interact with key behavioral, neuroendocrine, and autonomic regulatory regions of the central nervous system. Additionally, we offer a model in which hormones such as leptin and ghrelin interact with similar central nervous system circuits and engage them in such a way as to maintain an appropriate and tight regulation of body weight and food intake. Our model predicts that overstimulation or understimulation of these central pathways can result in obesity, anorexia, or cachexia.

AB - Over the past decade, there has been a tremendous increase in the understanding of the molecular and neural mechanisms that control food intake and body weight. Yet eating disorders and cachexia are still common, and obesity cases are rising at alarming rates. Thus, despite recent progress, an increased understanding of the molecular and neural substrates that control body weight homeostasis is a major public health goal. In this review, we discuss the mechanisms by which metabolic signals interact with key behavioral, neuroendocrine, and autonomic regulatory regions of the central nervous system. Additionally, we offer a model in which hormones such as leptin and ghrelin interact with similar central nervous system circuits and engage them in such a way as to maintain an appropriate and tight regulation of body weight and food intake. Our model predicts that overstimulation or understimulation of these central pathways can result in obesity, anorexia, or cachexia.

UR - http://www.scopus.com/inward/record.url?scp=0043030280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0043030280&partnerID=8YFLogxK

U2 - 10.1210/en.2003-0241

DO - 10.1210/en.2003-0241

M3 - Article

C2 - 12933644

AN - SCOPUS:0043030280

VL - 144

SP - 3749

EP - 3756

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 9

ER -