Minireview: Nuclear receptor regulation of osteoclast and bone remodeling

Zixue Jin, Xiaoxiao Li, Yihong Wan

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Osteoclasts are bone-resorbing cells essential for skeletal remodeling and regeneration. However, excessive osteoclasts often contribute to prevalent bone degenerative diseases such as osteoporosis, arthritis, and cancer bone metastasis. Osteoclast dysregulation is also associated with rare disorders such as osteopetrosis, pycnodysostosis, Paget’s disease, and Gorham-Stout syndrome. The nuclear receptor (NR) family of transcription factors functions as metabolic sensors that control a variety of physiological processes including skeletal homeostasis and serves as attractive therapeutic targets for many diseases. In this review, we highlight recent findings on the new players and the new mechanisms for how NRs regulate osteoclast differentiation and bone resorption. An enhanced understanding of NR functions in osteoclastogenesis will facilitate the development of not only novel osteoprotective medicine but also prudent strategies to minimize the adverse skeletal effects of certain NR-targeting drugs for a better treatment of cancer and metabolic diseases.

Original languageEnglish (US)
Pages (from-to)172-186
Number of pages15
JournalMolecular Endocrinology
Volume29
Issue number2
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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