Minireview

Switching on progesterone receptor expression with duplex RNA

Bethany A. Janowski, David R. Corey

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

It has long been appreciated that gene expression is regulated by protein complexes at promoters. More recently, research has demonstrated that small duplex RNAs such as micro-RNAs and short interfering RNAs complementary to mRNA provide another layer of regulation. Evidence now supports the existence of regulatory pathways that use small duplex RNAs to control transcription. Synthetic RNAs complementary to gene promoters [antigene RNAs (agRNAs)] can either activate or inhibit gene expression. Activity of agRNAs is mediated by argonaute, a protein required for RNA interference. Unlike protein transcription factors, agRNAs do not bind to chromosomal DNA but recognize noncoding transcripts that overlap gene promoters or 3′-gene termini. This review describes recent studies with agRNAs and focuses on the robust and potent agRNA-mediated regulation of progesterone receptor. The ability of small RNAs to alter transcription provides a new layer of potential regulation for gene expression.

Original languageEnglish (US)
Pages (from-to)2243-2252
Number of pages10
JournalMolecular Endocrinology
Volume24
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Progesterone Receptors
RNA
Argonaute Proteins
Genes
Gene Expression
Complementary RNA
Gene Expression Regulation
RNA Interference
MicroRNAs
Small Interfering RNA
Proteins
Transcription Factors
Messenger RNA
DNA
Research

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

Cite this

Minireview : Switching on progesterone receptor expression with duplex RNA. / Janowski, Bethany A.; Corey, David R.

In: Molecular Endocrinology, Vol. 24, No. 12, 12.2010, p. 2243-2252.

Research output: Contribution to journalArticle

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