miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion

Jun Huang, Bin Wang, Ke Hui, Jin Zeng, Jinhai Fan, Xinyang Wang, Jer Tsong Hsieh, Dalin He, Kaijie Wu

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Muscle-invasive or metastatic bladder cancer (BCa) has a very poor prognosis; however, its mechanisms remain largely unknown. Previous studies have discovered multiple microRNAs (miRs) that are involved in BCa progression and regarded as potential biomarkers or therapeutic targets. In this study, we demonstrated that miR-92b could uniquely promote cell migration and invasion of BCa cells, but had no effect on cell proliferation. Mechanistically, our data provided evidence to verify that miR-92b was able to directly target DAB2IP, a well-known tumor suppressor, and inhibit epithelial-mesenchymal transition of BCa cells. Moreover, the increased expression levels of miR-92b were negatively correlated with DAB2IP, and predicted poor prognosis of patients with BCa. Overall, this study reveals a new promising biomarker and its mechanisms contributing to BCa invasion or metastasis.

Original languageEnglish (US)
Pages (from-to)1693-1701
Number of pages9
JournalOncology reports
Volume36
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • Bladder cancer
  • DAB2IP
  • Epith elial-mesenchymal transition
  • MicroRNA-92b

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Huang, J., Wang, B., Hui, K., Zeng, J., Fan, J., Wang, X., Hsieh, J. T., He, D., & Wu, K. (2016). miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion. Oncology reports, 36(3), 1693-1701. https://doi.org/10.3892/or.2016.4940