miRiad Roles for the miR-17-92 Cluster in Development and Disease

Research output: Contribution to journalArticle

810 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalCell
Volume133
Issue number2
DOIs
StatePublished - Apr 18 2008

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MicroRNAs
Tumors
Neoplasms
Immune system
Cell proliferation
Oncogenes
Immune System
Cells
Cell Proliferation
Apoptosis
Lung

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

miRiad Roles for the miR-17-92 Cluster in Development and Disease. / Mendell, Joshua T.

In: Cell, Vol. 133, No. 2, 18.04.2008, p. 217-222.

Research output: Contribution to journalArticle

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