Misidentification of unstable, low oxygen affinity hemoglobin variant

Joanna Jung, Emily Garnett, Beverley Vispo, Xinpu Chen, Jing Cao, M. Tarek Elghetany, Sridevi Devaraj

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We present a case of Hemoglobin (Hgb) Louisville in a 6-y old girl presenting with hypoxia and mild hemolytic anemia. Methods: Hgb Louisville is a rare, unstable hemoglobin variant with low oxygen affinity, but initial workup of this case using widely-available hemoglobin fractionation methods was unable to differentiate this variant from normal hemoglobins. Results: This resulted in a delayed diagnosis. Conclusion: This case highlights the limitations of routine hemoglobin fractionation methods for correct diagnosis of hemoglobin variants, and subsequent impact on patient care and management.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalClinica Chimica Acta
Volume509
DOIs
StatePublished - Oct 2020
Externally publishedYes

Keywords

  • Hemoglobin Louisville
  • Hemoglobin variant
  • Hemoglobinopathy

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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