Abstract
Background: We present a case of Hemoglobin (Hgb) Louisville in a 6-y old girl presenting with hypoxia and mild hemolytic anemia. Methods: Hgb Louisville is a rare, unstable hemoglobin variant with low oxygen affinity, but initial workup of this case using widely-available hemoglobin fractionation methods was unable to differentiate this variant from normal hemoglobins. Results: This resulted in a delayed diagnosis. Conclusion: This case highlights the limitations of routine hemoglobin fractionation methods for correct diagnosis of hemoglobin variants, and subsequent impact on patient care and management.
Original language | English (US) |
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Pages (from-to) | 177-179 |
Number of pages | 3 |
Journal | Clinica Chimica Acta |
Volume | 509 |
DOIs | |
State | Published - Oct 2020 |
Externally published | Yes |
Keywords
- Hemoglobin Louisville
- Hemoglobin variant
- Hemoglobinopathy
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Biochemistry, medical