Mitochondrial biogenesis in the acutely injured kidney

Mei Tran, Samir M. Parikh

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Mitochondrial dysfunction within the tubular epithelium has been implicated in the pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults dysregulate mitochondrial dynamics, resulting in mitochondrial swelling, fission, and apoptosis. The coordinated processes of generating healthy mitochondria and clearing damaged organelles may contribute to the preservation and restoration of mitochondrial homeostasis. Emerging literature suggests that a master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor-γ-coactivator-1α (PGC-1α), is highly expressed in the tubular epithelium of the healthy kidney, and its induction during the post-injury period may contribute to functional recovery from acute kidney injury.

Original languageEnglish (US)
Pages (from-to)42-45
Number of pages4
JournalNephron - Clinical Practice
Volume127
Issue number1-4
DOIs
StatePublished - Apr 16 2014
Externally publishedYes

Keywords

  • Acute kidney injury
  • Biogenesis
  • Mitochondrial function
  • Mitophagy
  • Renal recovery

ASJC Scopus subject areas

  • Nephrology

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