Mitochondrial DNA Haplotypes as Genetic Modifiers of Cancer

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Mitochondria play an essential role in cellular metabolism, generation of reactive oxygen species (ROS), and the initiation of apoptosis. These properties enable mitochondria to be crucial integrators in the pathways of tumorigenesis. An open question is to what extent variation in the mitochondrial genome (mtDNA) contributes to the biological heterogeneity observed in human tumors. In this review, we summarize our current understanding of the role of mtDNA genetics in relation to human cancers.

Original languageEnglish (US)
Pages (from-to)1044-1058
Number of pages15
JournalTrends in Cancer
Volume6
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • cancer
  • haplotypes
  • mitochondria
  • mtDNA
  • oncocytoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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