Mitochondrial dynamics and inheritance during cell division, development and disease

Prashant Mishra, David C. Chan

Research output: Contribution to journalReview article

391 Scopus citations

Abstract

During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features-including their own genome and a maternal mode of germline transmission-that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion-fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.

Original languageEnglish (US)
Pages (from-to)634-646
Number of pages13
JournalNature Reviews Molecular Cell Biology
Volume15
Issue number10
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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