TY - JOUR
T1 - Mitochondrial dynamics and inheritance during cell division, development and disease
AU - Mishra, Prashant
AU - Chan, David C.
N1 - Funding Information:
P.M. is supported by a Baxter Postdoctoral Fellowship. Work in laboratory of D.C.C. is supported by the US National Institutes of Health grants GM062967 and GM110039, the Muscular Dystrophy Association and the Howard Hughes Medical Institute.
Publisher Copyright:
© 2014 Macmillan Publishers Limited. All rights reserved.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features-including their own genome and a maternal mode of germline transmission-that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion-fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.
AB - During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features-including their own genome and a maternal mode of germline transmission-that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion-fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.
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U2 - 10.1038/nrm3877
DO - 10.1038/nrm3877
M3 - Review article
C2 - 25237825
AN - SCOPUS:84910141948
SN - 1471-0072
VL - 15
SP - 634
EP - 646
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 10
ER -