TY - JOUR
T1 - Mitochondrial dysfunction in white adipose tissue
AU - Kusminski, Christine M.
AU - Scherer, Philipp E.
N1 - Funding Information:
We would kindly like to thank Jiyoung Park for providing helpful assistance in the construction and graphics of Figure 1 . The authors were supported by National Institutes of Health grants R01-DK55758, RC1 DK086629 and P01DK088761 (P.E.S.). C.M.K. was supported by a fellowship from the Juvenile Diabetes Foundation (JDRF 3-2008-130).
PY - 2012/9
Y1 - 2012/9
N2 - Although mitochondria in brown adipose tissue and their role in non-shivering thermogenesis have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue (WAT) for cellular homeostasis of the adipocyte and their impact upon systemic energy homeostasis. A better understanding of the regulatory role that white adipocyte mitochondria play in the regulation of whole-body physiology becomes increasingly important. WAT mitochondrial biogenesis can effectively be induced pharmacologically using a number of agents, including PPARγ agonists. Through their ability to influence key biochemical processes central to the adipocyte, such as fatty acid (FA) esterification and lipogenesis, as well as their impact upon the production and release of key adipokines, mitochondria play a crucial role in determining systemic insulin sensitivity.
AB - Although mitochondria in brown adipose tissue and their role in non-shivering thermogenesis have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue (WAT) for cellular homeostasis of the adipocyte and their impact upon systemic energy homeostasis. A better understanding of the regulatory role that white adipocyte mitochondria play in the regulation of whole-body physiology becomes increasingly important. WAT mitochondrial biogenesis can effectively be induced pharmacologically using a number of agents, including PPARγ agonists. Through their ability to influence key biochemical processes central to the adipocyte, such as fatty acid (FA) esterification and lipogenesis, as well as their impact upon the production and release of key adipokines, mitochondria play a crucial role in determining systemic insulin sensitivity.
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U2 - 10.1016/j.tem.2012.06.004
DO - 10.1016/j.tem.2012.06.004
M3 - Article
C2 - 22784416
AN - SCOPUS:84865440201
SN - 1043-2760
VL - 23
SP - 435
EP - 443
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 9
ER -