Mitochondrial form and function

Jonathan R. Friedman, Jodi Nunnari

Research output: Contribution to journalReview article

483 Citations (Scopus)

Abstract

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.

Original languageEnglish (US)
Pages (from-to)335-343
Number of pages9
JournalNature
Volume505
Issue number7483
DOIs
StatePublished - Jan 22 2014
Externally publishedYes

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Eukaryotic Cells
Mitochondria
Mitochondrial Size
Organelles
Respiration
Chromosomes
Adenosine Triphosphate
Genome

ASJC Scopus subject areas

  • General

Cite this

Mitochondrial form and function. / Friedman, Jonathan R.; Nunnari, Jodi.

In: Nature, Vol. 505, No. 7483, 22.01.2014, p. 335-343.

Research output: Contribution to journalReview article

Friedman, JR & Nunnari, J 2014, 'Mitochondrial form and function', Nature, vol. 505, no. 7483, pp. 335-343. https://doi.org/10.1038/nature12985
Friedman, Jonathan R. ; Nunnari, Jodi. / Mitochondrial form and function. In: Nature. 2014 ; Vol. 505, No. 7483. pp. 335-343.
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