Mitochondrial form and function

Jonathan R. Friedman, Jodi Nunnari

Research output: Contribution to journalReview article

534 Scopus citations


Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.

Original languageEnglish (US)
Pages (from-to)335-343
Number of pages9
Issue number7483
StatePublished - Jan 22 2014


ASJC Scopus subject areas

  • General

Cite this