Mitochondrial protein oxidation and degradation in response to oxidative stress and aging

Anne Laure Bulteau, Luke I. Szweda, Bertrand Friguet

Research output: Contribution to journalShort survey

109 Scopus citations

Abstract

Mitochondria are a major source of intracellular reactive oxygen species (ROS), the production of which increases with age. These organelles are also targets of oxidative damage. The deleterious effects of ROS may be responsible for impairment of mitochondrial function observed during various pathophysiological states associated with oxidative stress and aging. An important factor for protein maintenance in the presence of oxidative stress is enzymatic reversal of oxidative modifications and/or protein degradation. Failure of these protein maintenance systems is likely a critical component of the aging process. Mitochondrial matrix proteins are sensitive to oxidative inactivation and oxidized proteins are known to accumulate during aging. The ATP-stimulated mitochondrial Lon protease is a highly conserved protease found in prokaryotes and the mitochondrial compartment of eukaryotes and is believed to play an important role in the degradation of oxidized mitochondrial matrix proteins. Age-dependent declines in the activity and regulation of this proteolytic system may underlie accumulation of oxidatively modified and dysfunctional protein and loss in mitochondrial viability.

Original languageEnglish (US)
Pages (from-to)653-657
Number of pages5
JournalExperimental Gerontology
Volume41
Issue number7
DOIs
StatePublished - Jul 1 2006

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Keywords

  • Aging
  • Ischemia-reperfusion
  • Lon protease
  • Mitochondrial protein degradation
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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