Mitogenic activity of high molecular polysaccharide fractions isolated from the cuppressaceae Thuja Occidentalis L. enhanced cytokine-production by thyapolysaccharide, g-fraction (TPSg)

R. Offergeld, C. Reinecker, E. Gumz, S. Schrum, R. Treiber, R. D. Neth, S. H. Gohla

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17 Scopus citations

Abstract

Thuja polysaccharide g fraction (TPSg) was shown to be an inducer of the CD4+ fraction of the human peripheral blood T-cell subset (1,2). Furthermore, it could be demonstrated that TPSg is a potent inhibitor of the expression of HIV-1-specific antigens and of the HIV-1-specific reverse transcriptase (3). This report deals with the cytokine pattern induced by TPSg in human peripheral blood lymphocyte (PBL) and purified monocyte/macrophage cultures. In addition, a further characterization of the CD4+ T-cell fraction stimulated by TPSg was performed by FACS analysis. TPSg is induces IL-Iβ, IL-2, IL-3, IL-6, γ-IFN, G-CSF, GM-CSF, and TNF-β production in PBL cultures; and IL-1β and IL-6 in monocyte/macronphage cultures. Enzyme-linked immunosorbent assays (ELISAs) demonstrated that no IL-4 was produced by PBL cultures under TPSg influence.

Original languageEnglish (US)
Pages (from-to)189S-191S
JournalLeukemia
Volume6
Issue numberSUPPL. 3
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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