Mitosis: Short-circuiting spindle checkpoint signaling

Xuelian Luo, Hongtao Yu

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

Original languageEnglish (US)
Pages (from-to)R128-R130
JournalCurrent Biology
Volume22
Issue number4
DOIs
StatePublished - Feb 21 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Mitosis: Short-circuiting spindle checkpoint signaling'. Together they form a unique fingerprint.

  • Cite this