Mitosis: Short-circuiting spindle checkpoint signaling

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.

Original languageEnglish (US)
JournalCurrent Biology
Volume22
Issue number4
DOIs
StatePublished - Feb 21 2012

Fingerprint

Anaphase-Promoting Complex-Cyclosome
Kinetochores
kinetochores
Anaphase
Saccharomycetales
anaphase
endpoints
Mitosis
mitosis
yeasts
Yeast
Networks (circuits)
Experiments
anaphase promoting complex

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mitosis : Short-circuiting spindle checkpoint signaling. / Luo, Xuelian; Yu, Hongtao.

In: Current Biology, Vol. 22, No. 4, 21.02.2012.

Research output: Contribution to journalArticle

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