Mitotic division of the mammalian Golgi apparatus

Jen Hsuan Wei, Joachim Seemann

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Successful cell reproduction requires faithful duplication and proper segregation of cellular contents, including not only the genome but also intracellular organelles. Since the Golgi apparatus is an essential organelle of the secretory pathway, its accurate inheritance is therefore of importance to sustain cellular function. Regulation of Golgi division and its coordination with cell cycle progression involves a series of sequential events that are subjected to a precise spatiotemporal control. Here, we summarize the current knowledge about the underlying mechanisms, the molecular players and the biological relevance of this process, particularly in mammalian cells, and discuss the unsolved problems and future perspectives opened by the recent studies.

Original languageEnglish (US)
Pages (from-to)810-816
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume20
Issue number7
DOIs
StatePublished - Sep 2009

Fingerprint

Golgi Apparatus
Organelles
Biological Phenomena
Secretory Pathway
Reproduction
Cell Cycle
Genome

Keywords

  • Golgi
  • Mitosis
  • Organelle inheritance
  • Ribbon
  • Spindle

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Mitotic division of the mammalian Golgi apparatus. / Wei, Jen Hsuan; Seemann, Joachim.

In: Seminars in Cell and Developmental Biology, Vol. 20, No. 7, 09.2009, p. 810-816.

Research output: Contribution to journalArticle

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