Mixed lymphocyte culture typing cells from patients with rheumatoid arthritis

P. Stastny

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Patients with rheumatoid arthritis were investigated as a possible source of mixed lymphocyte culture (MLC) typing cells. Lymphocytes from 4 patients that were non stimulatory for unrelated subjects suffering from the same disease were chosen for a preliminary analysis. Patterns of reactions obtained were interpreted as being due to LS lymphocyte stimulating specificities Ra, Rb, Rc, Rd and r. Ra was found to be included in all R types, but r and R appeared to be mutually exclusive. Ra was found also in a subject from a normal family, where it was inherited in association with a maternal haplotype HL A2, W10. In unrelated individuals these antigens did not show association with any particular HL A antigens. The methods described may offer a practical approach for further identification and study of MLC determinants.

Original languageEnglish (US)
Pages (from-to)571-579
Number of pages9
JournalTissue Antigens
Volume4
Issue number6
StatePublished - 1974

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Rheumatoid Arthritis
Cell Culture Techniques
Lymphocytes
HLA Antigens
varespladib methyl
Haplotypes
Mothers
Antigens

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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Mixed lymphocyte culture typing cells from patients with rheumatoid arthritis. / Stastny, P.

In: Tissue Antigens, Vol. 4, No. 6, 1974, p. 571-579.

Research output: Contribution to journalArticle

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