Mixture in the distribution of haloperidol-induced oral dyskinesias in the rat supports an animal model of tardive dyskinesia

Takeshi Hashimoto, David E. Ross, Xue Min Gao, Deborah R. Medoff, Carol A. Tamminga

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Spontaneous adventitious oral movements which are produced in rats by very chronic (6-month) neuroleptic treatment have some phenomenologic and pharmacologic characteristics in common with tardive dyskinesia in humans. However, since not all of the features match, this putative model has been questioned and further support is warranted. Data from several laboratories support dichotomizing these neuroleptic-induced rat oral movements into 'low' or 'not TD-like' movements and 'high' or 'TD-like' movements, similar to the division of neuroleptic-induced involuntary movements in humans. Here, we have used mixture analysis to test this proposal statistically in 185 haloperidol-treated and 127 water-treated animals. Rats from several different studies were grouped together to form these two cohorts. The haloperidol dose, route of administration, rating technique, and balanced experimental groups were held constant across all experiments. Results show that two distinct groups of rat movements are induced by very chronic haloperidol treatment (1.5 mg/kg per day). The 'low' vacuous chewing movement (VCM) group of rats had an average of 3.6 VCMs/5 min, and the 'high' VCM group had an average of 16.1 VCMs/5 min; the control group, with a median VCM rate of 2.0 VCMs/5 min, demonstrated a single distribution. These data suggest that rats, like humans, dichotomize into two groups either expressing or not expressing 'high' VCM dyskinesias with very chronic haloperidol treatment.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalPsychopharmacology
Volume137
Issue number2
DOIs
StatePublished - 1998

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Movement Disorders
Haloperidol
Animal Models
Mastication
Antipsychotic Agents
Dyskinesias
Tardive Dyskinesia
Control Groups
Water

Keywords

  • Chronic haloperidol
  • Mixture analysis
  • Rats
  • Tardive dyskinesia
  • Vacuous chewing movements

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mixture in the distribution of haloperidol-induced oral dyskinesias in the rat supports an animal model of tardive dyskinesia. / Hashimoto, Takeshi; Ross, David E.; Gao, Xue Min; Medoff, Deborah R.; Tamminga, Carol A.

In: Psychopharmacology, Vol. 137, No. 2, 1998, p. 107-112.

Research output: Contribution to journalArticle

Hashimoto, Takeshi ; Ross, David E. ; Gao, Xue Min ; Medoff, Deborah R. ; Tamminga, Carol A. / Mixture in the distribution of haloperidol-induced oral dyskinesias in the rat supports an animal model of tardive dyskinesia. In: Psychopharmacology. 1998 ; Vol. 137, No. 2. pp. 107-112.
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