TY - GEN
T1 - Model-Based Indices of Early-Stage Cardiovascular Failure and Its Therapeutic Management in Fontan Patients
AU - Ruijsink, Bram
AU - Zugaj, Konrad
AU - Pushparajah, Kuberan
AU - Chabiniok, Radomír
N1 - Funding Information:
Acknowledgments. The authors acknowledge financial support from the Department of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and the NIHR Cardiovascular MedTech Co-operative (previously existing as the Cardiovascular Healthcare Technology Co-operative 2012–2017), the support of Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z], and from the Inria Associated team ToFMOD. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.
Funding Information:
The authors acknowledge financial support from the Department of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s & St Thomas’ NHS Foundation Trust in partnership with King’s College London and the NIHR Cardiovascular MedTech Co-operative (previously existing as the Cardiovascular Healthcare Technology Co-operative 2012–2017), the support of Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z], and from the Inria Associated team ToFMOD. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. In addition, the authors would like to acknowledge Philippe Moireau and Dominique Chapelle, Inria research team MΞDISIM, for providing the cardiac simulation software CardiacLab under a Royalty-fee software license.
Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019
Y1 - 2019
N2 - Investigating the causes of failure of Fontan circulation in individual patients remains challenging despite detailed combined invasive cardiac catheterisation and magnetic resonance (XMR) exams at rest and during stress. In this work, we use a biomechanical model of the heart and Fontan circulation with the components of systemic and pulmonary beds to augment the diagnostic assessment of patients undergoing the XMR stress exam. We apply our model in 3 Fontan patients and one biventricular “control” case. In all subjects, we obtained important biophysical factors of cardiovascular physiology – contractility, contractile reserve and changes in systemic and pulmonary vascular resistance – which contribute to explaining the mechanism of failure in individual patients. Finally, we used the patient-specific model of one Fontan patient to investigate the impact of changes in pulmonary vascular resistance, aiming at in silico testing of pulmonary vasodilation treatments.
AB - Investigating the causes of failure of Fontan circulation in individual patients remains challenging despite detailed combined invasive cardiac catheterisation and magnetic resonance (XMR) exams at rest and during stress. In this work, we use a biomechanical model of the heart and Fontan circulation with the components of systemic and pulmonary beds to augment the diagnostic assessment of patients undergoing the XMR stress exam. We apply our model in 3 Fontan patients and one biventricular “control” case. In all subjects, we obtained important biophysical factors of cardiovascular physiology – contractility, contractile reserve and changes in systemic and pulmonary vascular resistance – which contribute to explaining the mechanism of failure in individual patients. Finally, we used the patient-specific model of one Fontan patient to investigate the impact of changes in pulmonary vascular resistance, aiming at in silico testing of pulmonary vasodilation treatments.
KW - Dobutamine stress
KW - Fontan circulation
KW - Heart failure
KW - Pulmonary vascular resistance
KW - Pulmonary vasodilation therapy
UR - http://www.scopus.com/inward/record.url?scp=85067208869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067208869&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-21949-9_41
DO - 10.1007/978-3-030-21949-9_41
M3 - Conference contribution
AN - SCOPUS:85067208869
SN - 9783030219482
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 379
EP - 387
BT - Functional Imaging and Modeling of the Heart - 10th International Conference, FIMH 2019, Proceedings
A2 - Ozenne, Valéry
A2 - Vigmond, Edward
A2 - Coudière, Yves
A2 - Zemzemi, Nejib
PB - Springer Verlag
T2 - 10th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2019
Y2 - 6 June 2019 through 8 June 2019
ER -