Model-Based Indices of Early-Stage Cardiovascular Failure and Its Therapeutic Management in Fontan Patients

Bram Ruijsink, Konrad Zugaj, Kuberan Pushparajah, Radomír Chabiniok

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Investigating the causes of failure of Fontan circulation in individual patients remains challenging despite detailed combined invasive cardiac catheterisation and magnetic resonance (XMR) exams at rest and during stress. In this work, we use a biomechanical model of the heart and Fontan circulation with the components of systemic and pulmonary beds to augment the diagnostic assessment of patients undergoing the XMR stress exam. We apply our model in 3 Fontan patients and one biventricular “control” case. In all subjects, we obtained important biophysical factors of cardiovascular physiology – contractility, contractile reserve and changes in systemic and pulmonary vascular resistance – which contribute to explaining the mechanism of failure in individual patients. Finally, we used the patient-specific model of one Fontan patient to investigate the impact of changes in pulmonary vascular resistance, aiming at in silico testing of pulmonary vasodilation treatments.

Original languageEnglish (US)
Title of host publicationFunctional Imaging and Modeling of the Heart - 10th International Conference, FIMH 2019, Proceedings
EditorsValéry Ozenne, Edward Vigmond, Yves Coudière, Nejib Zemzemi
PublisherSpringer Verlag
Pages379-387
Number of pages9
ISBN (Print)9783030219482
DOIs
StatePublished - 2019
Externally publishedYes
Event10th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2019 - Bordeaux, France
Duration: Jun 6 2019Jun 8 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11504 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference10th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2019
Country/TerritoryFrance
CityBordeaux
Period6/6/196/8/19

Keywords

  • Dobutamine stress
  • Fontan circulation
  • Heart failure
  • Pulmonary vascular resistance
  • Pulmonary vasodilation therapy

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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