TY - GEN
T1 - Modeling adhesion dynamics of nanoparticles
T2 - 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009
AU - Shah, Samar
AU - Liu, Yaling
AU - Hu, Wenchuang
AU - Gao, Jinming
PY - 2009
Y1 - 2009
N2 - Adhesion of micro and nanoparticles onto cardiovascular walls is a critical process in applications such as targeted drug delivery, biomedical imaging, and cancer treatment. This paper intends to develop an understanding of the dynamic interaction between particle and vessel wall through computational modeling. The ligand-receptor binding dynamics is coupled with Immersed Finite Element Method to study the adhesion process of particles with different shapes, bonding strengths, and physical configurations. Non-spherical particle is found to contact and adhere to the wall easier than spherical particle under the same configuration. This research work will help design of micro/nanoparticles for enhanced targeted adhesion to cells of interest.
AB - Adhesion of micro and nanoparticles onto cardiovascular walls is a critical process in applications such as targeted drug delivery, biomedical imaging, and cancer treatment. This paper intends to develop an understanding of the dynamic interaction between particle and vessel wall through computational modeling. The ligand-receptor binding dynamics is coupled with Immersed Finite Element Method to study the adhesion process of particles with different shapes, bonding strengths, and physical configurations. Non-spherical particle is found to contact and adhere to the wall easier than spherical particle under the same configuration. This research work will help design of micro/nanoparticles for enhanced targeted adhesion to cells of interest.
UR - http://www.scopus.com/inward/record.url?scp=70349983815&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349983815&partnerID=8YFLogxK
U2 - 10.1109/BSEC.2009.5090484
DO - 10.1109/BSEC.2009.5090484
M3 - Conference contribution
AN - SCOPUS:70349983815
SN - 9781424438372
T3 - 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009
BT - 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009
Y2 - 18 March 2009 through 19 March 2009
ER -