Modeling adhesion dynamics of nanoparticles: The effect of flow rates and ligand density

Samar Shah, Yaling Liu, Wenchuang Hu, Jinming Gao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Adhesion of micro and nanoparticles onto cardiovascular walls is a critical process in applications such as targeted drug delivery, biomedical imaging, and cancer treatment. This paper intends to develop an understanding of the dynamic interaction between particle and vessel wall through computational modeling. The ligand-receptor binding dynamics is coupled with Immersed Finite Element Method to study the adhesion process of particles with different shapes, bonding strengths, and physical configurations. Non-spherical particle is found to contact and adhere to the wall easier than spherical particle under the same configuration. This research work will help design of micro/nanoparticles for enhanced targeted adhesion to cells of interest.

Original languageEnglish (US)
Title of host publication2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009
DOIs
StatePublished - 2009
Event2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009 - Oak Ridge, TN, United States
Duration: Mar 18 2009Mar 19 2009

Other

Other2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009
CountryUnited States
CityOak Ridge, TN
Period3/18/093/19/09

Fingerprint

Nanoparticles
Adhesion
Ligands
Flow rate
Cell Adhesion
Oncology
Particle interactions
Research
Pharmaceutical Preparations
Imaging techniques
Finite element method
Neoplasms
Targeted drug delivery

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Shah, S., Liu, Y., Hu, W., & Gao, J. (2009). Modeling adhesion dynamics of nanoparticles: The effect of flow rates and ligand density. In 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009 [5090484] https://doi.org/10.1109/BSEC.2009.5090484

Modeling adhesion dynamics of nanoparticles : The effect of flow rates and ligand density. / Shah, Samar; Liu, Yaling; Hu, Wenchuang; Gao, Jinming.

2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009. 2009. 5090484.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shah, S, Liu, Y, Hu, W & Gao, J 2009, Modeling adhesion dynamics of nanoparticles: The effect of flow rates and ligand density. in 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009., 5090484, 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009, Oak Ridge, TN, United States, 3/18/09. https://doi.org/10.1109/BSEC.2009.5090484
Shah S, Liu Y, Hu W, Gao J. Modeling adhesion dynamics of nanoparticles: The effect of flow rates and ligand density. In 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009. 2009. 5090484 https://doi.org/10.1109/BSEC.2009.5090484
Shah, Samar ; Liu, Yaling ; Hu, Wenchuang ; Gao, Jinming. / Modeling adhesion dynamics of nanoparticles : The effect of flow rates and ligand density. 2009 1st Annual ORNL Biomedical Science and Engineering Conference, BSEC 2009. 2009.
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