Modeling of region-specific fMRI BOLD neurovascular response functions in rat brain reveals residual differences that correlate with the differences in regional evoked potentials

Christopher P. Pawela, Anthony G. Hudetz, B. Douglas Ward, Marie L. Schulte, Rupeng Li, Dennis S. Kao, Matthew C. Mauck, Younghoon R. Cho, Jay Neitz, James S. Hyde

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The response of the rat visual system to flashes of blue light has been studied by blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). The BOLD temporal response is dependent on the number of flashes presented and demonstrates a refractory period that depends on flash frequency. Activated brain regions included the primary and secondary visual cortex, superior colliculus (SC), dorsal lateral geniculate (DLG), and lateral posterior nucleus (LP), which were found to exhibit differing temporal responses. To explain these differences, the BOLD neurovascular response function was modeled. A second-order differential equation was developed and solved numerically to arrive at region-specific response functions. Included in the model are the light input from the diode (duty cycle), a refractory period, a transient response following onset and cessation of stimulus, and a slow adjustment to changes in the average level of the signal. Constants in the differential equation were evaluated for each region by fitting the model to the experimental BOLD response from a single flash, and the equation was then solved for multiple flashes. The simulation mimics the major features of the data; however, remaining differences in the frequency dependence of the response between the cortical and subcortical regions were unexplained. We hypothesized that these discrepancies were due to regional-specific differences in neuronal response to flash frequency. To test this hypothesis, cortical visual evoked potentials (VEPs) were recorded using the same stimulation protocol as the fMRI. Cortical VEPs were more suppressed than subcortical VEPs as flash frequency increased, supporting our hypothesis. This is the first report that regional differences in neuronal activation to the same stimulus lead to differential BOLD activation.

Original languageEnglish (US)
Pages (from-to)525-534
Number of pages10
JournalNeuroImage
Volume41
Issue number2
DOIs
StatePublished - Jun 2008

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Evoked Potentials
Magnetic Resonance Imaging
Visual Evoked Potentials
Oxygen
Brain
Lateral Thalamic Nuclei
Light
Superior Colliculi
Visual Cortex
Theoretical Models

Keywords

  • BOLD signal
  • Hemodynamic response modeling
  • Neuronal adaptation
  • Rat brain fMRI
  • Visual evoked potentials
  • Visual system

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Modeling of region-specific fMRI BOLD neurovascular response functions in rat brain reveals residual differences that correlate with the differences in regional evoked potentials. / Pawela, Christopher P.; Hudetz, Anthony G.; Ward, B. Douglas; Schulte, Marie L.; Li, Rupeng; Kao, Dennis S.; Mauck, Matthew C.; Cho, Younghoon R.; Neitz, Jay; Hyde, James S.

In: NeuroImage, Vol. 41, No. 2, 06.2008, p. 525-534.

Research output: Contribution to journalArticle

Pawela, Christopher P. ; Hudetz, Anthony G. ; Ward, B. Douglas ; Schulte, Marie L. ; Li, Rupeng ; Kao, Dennis S. ; Mauck, Matthew C. ; Cho, Younghoon R. ; Neitz, Jay ; Hyde, James S. / Modeling of region-specific fMRI BOLD neurovascular response functions in rat brain reveals residual differences that correlate with the differences in regional evoked potentials. In: NeuroImage. 2008 ; Vol. 41, No. 2. pp. 525-534.
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