Modeling stromal-epithelial interactions in disease progression.

Douglas W. Strand, Simon W. Hayward

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The role of tumor stroma in progression to malignancy has become the subject of intense experimental and clinical interest. The stromal compartment of organs is composed of all the non-epithelial cell types and maintains the proper architecture and nutrient levels required for epithelial and, ultimately, organ function. The composition of the reactive stroma surrounding tumors is vastly different from normal stromal tissue. Stromal phenotype can be correlated with, and predictive of, disease recurrence. In addition, the stroma is now seen as a legitimate target for therapeutic intervention. Although much has been learned about the role of the stromal compartment in development and disease in recent years, a number of key questions remain. Here we review how some of these questions are beginning to be addressed using new models of stromal-epithelial interaction.

Original languageEnglish (US)
Pages (from-to)504-511
Number of pages8
JournalDiscovery medicine
Volume9
Issue number49
StatePublished - Jun 2010

Fingerprint

Disease Progression
Neoplasms
Phenotype
Recurrence
Food
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Modeling stromal-epithelial interactions in disease progression. / Strand, Douglas W.; Hayward, Simon W.

In: Discovery medicine, Vol. 9, No. 49, 06.2010, p. 504-511.

Research output: Contribution to journalArticle

@article{a4ee7551a6e84f5caf8a2f9c142276b8,
title = "Modeling stromal-epithelial interactions in disease progression.",
abstract = "The role of tumor stroma in progression to malignancy has become the subject of intense experimental and clinical interest. The stromal compartment of organs is composed of all the non-epithelial cell types and maintains the proper architecture and nutrient levels required for epithelial and, ultimately, organ function. The composition of the reactive stroma surrounding tumors is vastly different from normal stromal tissue. Stromal phenotype can be correlated with, and predictive of, disease recurrence. In addition, the stroma is now seen as a legitimate target for therapeutic intervention. Although much has been learned about the role of the stromal compartment in development and disease in recent years, a number of key questions remain. Here we review how some of these questions are beginning to be addressed using new models of stromal-epithelial interaction.",
author = "Strand, {Douglas W.} and Hayward, {Simon W.}",
year = "2010",
month = "6",
language = "English (US)",
volume = "9",
pages = "504--511",
journal = "Discovery medicine",
issn = "1539-6509",
publisher = "Discovery Medicine",
number = "49",

}

TY - JOUR

T1 - Modeling stromal-epithelial interactions in disease progression.

AU - Strand, Douglas W.

AU - Hayward, Simon W.

PY - 2010/6

Y1 - 2010/6

N2 - The role of tumor stroma in progression to malignancy has become the subject of intense experimental and clinical interest. The stromal compartment of organs is composed of all the non-epithelial cell types and maintains the proper architecture and nutrient levels required for epithelial and, ultimately, organ function. The composition of the reactive stroma surrounding tumors is vastly different from normal stromal tissue. Stromal phenotype can be correlated with, and predictive of, disease recurrence. In addition, the stroma is now seen as a legitimate target for therapeutic intervention. Although much has been learned about the role of the stromal compartment in development and disease in recent years, a number of key questions remain. Here we review how some of these questions are beginning to be addressed using new models of stromal-epithelial interaction.

AB - The role of tumor stroma in progression to malignancy has become the subject of intense experimental and clinical interest. The stromal compartment of organs is composed of all the non-epithelial cell types and maintains the proper architecture and nutrient levels required for epithelial and, ultimately, organ function. The composition of the reactive stroma surrounding tumors is vastly different from normal stromal tissue. Stromal phenotype can be correlated with, and predictive of, disease recurrence. In addition, the stroma is now seen as a legitimate target for therapeutic intervention. Although much has been learned about the role of the stromal compartment in development and disease in recent years, a number of key questions remain. Here we review how some of these questions are beginning to be addressed using new models of stromal-epithelial interaction.

UR - http://www.scopus.com/inward/record.url?scp=77957341243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957341243&partnerID=8YFLogxK

M3 - Article

C2 - 20587339

AN - SCOPUS:77957341243

VL - 9

SP - 504

EP - 511

JO - Discovery medicine

JF - Discovery medicine

SN - 1539-6509

IS - 49

ER -