Modeling the hemodynamic response to dopamine in acute heart failure

K. J. Gingrich, R. Roy, R. Vishnoi, C. Yu, G. W. Neat

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A nonlinear descriptive single-input-multiple-output (SIMO) model of the hemodynamic response (cardiac output and mean arterial pressure) in acute ischemic heart failure to the inotropic drug dopamine was developed to facilitate the design of closed-loop control systems. The structure of the cardiac-output component is a first order system with a sigmoidal relationship, while the mean-arteria-pressure component is a first-order system with a threshold. Overall, the model gave good approximations of mean empirical responses. Parameter identification was performed on positive step (drug on) and negative step (drug off) testing using multiple (2 mcg/kg/min-6 mcg/kg/min) infusions of dopamine in a canine model of acute ischemic heart failure. Parameter estimation utilized a least-squares objective function and a linearized form of the step response of the model in the time domain.

Original languageEnglish (US)
Title of host publicationIEEE/Engineering in Medicine and Biology Society Annual Conference
PublisherPubl by IEEE
Pages515-516
Number of pages2
Volume10
Editionpt2
Publication statusPublished - Nov 1988
EventProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA
Duration: Nov 4 1988Nov 7 1988

Other

OtherProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityNew Orleans, LA, USA
Period11/4/8811/7/88

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Gingrich, K. J., Roy, R., Vishnoi, R., Yu, C., & Neat, G. W. (1988). Modeling the hemodynamic response to dopamine in acute heart failure. In IEEE/Engineering in Medicine and Biology Society Annual Conference (pt2 ed., Vol. 10, pp. 515-516). Publ by IEEE.