Abstract
A nonlinear descriptive single-input-multiple-output (SIMO) model of the hemodynamic response (cardiac output and mean arterial pressure) in acute ischemic heart failure to the inotropic drug dopamine was developed to facilitate the design of closed-loop control systems. The structure of the cardiac-output component is a first order system with a sigmoidal relationship, while the mean-arteria-pressure component is a first-order system with a threshold. Overall, the model gave good approximations of mean empirical responses. Parameter identification was performed on positive step (drug on) and negative step (drug off) testing using multiple (2 mcg/kg/min-6 mcg/kg/min) infusions of dopamine in a canine model of acute ischemic heart failure. Parameter estimation utilized a least-squares objective function and a linearized form of the step response of the model in the time domain.
Original language | English (US) |
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Title of host publication | IEEE/Engineering in Medicine and Biology Society Annual Conference |
Publisher | Publ by IEEE |
Pages | 515-516 |
Number of pages | 2 |
Volume | 10 |
Edition | pt2 |
State | Published - Nov 1988 |
Event | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA Duration: Nov 4 1988 → Nov 7 1988 |
Other
Other | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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City | New Orleans, LA, USA |
Period | 11/4/88 → 11/7/88 |
ASJC Scopus subject areas
- General Engineering