Models of cardiac hypertrophy and transition to heart failure

Jeff M. Berry, R. Haris Naseem, Beverly A Rothermel, Joseph A Hill

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The prevalence of heart failure is increasing rapidly worldwide, and yet effective treatments remain elusive. Pathological remodeling of the ventricle - and associated hypertrophic growth, fibrotic change, cavity dilatation and electrophysiological remodeling - is a significant contributor to the pathogenesis of this prevalent disorder. As a consequence, there is great interest in developing new therapies to target pathological remodeling of the heart with the intent to prevent, arrest, or possibly reverse the otherwise inexorable progression of disease. To tackle this problem, numerous models of disease have been developed, both in vivo and in vitro. Here, we review models of cardiac hypertrophy and failure, compare and contrast their strengths and limitations, and on occasion cite recent works where the use of these models has contributed to significant scientific advances.

Original languageEnglish (US)
Pages (from-to)197-206
Number of pages10
JournalDrug Discovery Today: Disease Models
Volume4
Issue number4
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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