Moderators of antidepressant response in major depression.

Richard C. Shelton, Madhukar H. Trivedi

Research output: Contribution to journalComment/debate

8 Scopus citations

Abstract

Moderators are baseline variables that predict response to a treatment. Prognostic moderators predict response to all treatments, whereas prescriptive moderators predict differential response to particular treatments. In patients with major depressive disorder, prognostic variables include having anxious or chronic depression, living alone, and having psychiatric comorbidities. Prescriptive variables include gender, menopausal status, age and age at onset, depressive subtype, severity, and chronicity. Recognizing these variables can help clinicians better predict patients' response to treatment, select effective treatments for individual patients, and move patients to the next treatment step when response is inadequate.

Original languageEnglish (US)
Pages (from-to)e32
JournalThe Journal of clinical psychiatry
Volume72
Issue number10
StatePublished - Oct 2011

ASJC Scopus subject areas

  • Psychiatry and Mental health

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