Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia

Abbot R. Laptook, Ronald J T Corbett, Rick Sterett, Dennis K. Burns, Damian Garcia, Greg Tollefsbol

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Intraischemic reduction in temperature of 2-3°C (modest hypothermia) has been demonstrated to provide partial neuroprotection in neonatal animals. This investigation determined if modest hypothermia initiated immediately after brain ischemia provides neuroprotection. Piglets were studied with rectal temperature maintained during the 1st h after 15 min of brain ischemia at either 38.3 ± 0.3°C (normothermia, n = 11) or at 35.8 ± 0.5°C (modest hypothermia, n = 11). The severity of brain ischemia was similar between groups as indicated by equivalent reduction in mean blood pressure (90 ± 15 to 24 ± 3 versus 92 ± 13 to 26 ± 3 mm Hg), and changes in cerebral metabolites and intracellular pH (pH(i)) measured by magnetic resonance spectroscopy (β-nucleoside triphosphate = 44 ± 9 versus 42 ± 18% of control, control = 100%, pH(i): 6.25 ± .15 versus 6.24 ± 0.22 for normothermic and modestly hypothermic groups, respectively). In the first 90 min after ischemia, there were no differences between groups in the duration and extent of brain acidosis, and relative concentrations of phosphorylated metabolites. Categorical assessment of neurobehavior was evaluated at 72 h postischemia (n = 16), or earlier if an animal's condition deteriorated (n = 6). Postischemic hypothermia was associated with less severe stages of encephalopathy compared with normothermia (p = 0.05). Histologic neuronal injury was assessed categorically in 16 brain regions, and postischemic hypothermia resulted in less neuronal injury in temporal (p = 0.024) and occipital (p = 0.044) cortex at 10 mm beneath the cortical surface, and in the basal ganglia (p = 0.038) compared with that in normothermia. Modest hypothermia for 1 h immediately after brain ischemia provides partial neuroprotection and may represent an adjunct to resuscitative strategies.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalPediatric Research
Volume42
Issue number1
StatePublished - Jul 1997

Fingerprint

Hypothermia
Brain Ischemia
Resuscitation
Newborn Animals
Temperature
Wounds and Injuries
Brain
Brain Diseases
Acidosis
Basal Ganglia
Nucleosides
Neuroprotection
Magnetic Resonance Spectroscopy
Ischemia
Blood Pressure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Laptook, A. R., Corbett, R. J. T., Sterett, R., Burns, D. K., Garcia, D., & Tollefsbol, G. (1997). Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia. Pediatric Research, 42(1), 17-23.

Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia. / Laptook, Abbot R.; Corbett, Ronald J T; Sterett, Rick; Burns, Dennis K.; Garcia, Damian; Tollefsbol, Greg.

In: Pediatric Research, Vol. 42, No. 1, 07.1997, p. 17-23.

Research output: Contribution to journalArticle

Laptook, AR, Corbett, RJT, Sterett, R, Burns, DK, Garcia, D & Tollefsbol, G 1997, 'Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia', Pediatric Research, vol. 42, no. 1, pp. 17-23.
Laptook, Abbot R. ; Corbett, Ronald J T ; Sterett, Rick ; Burns, Dennis K. ; Garcia, Damian ; Tollefsbol, Greg. / Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia. In: Pediatric Research. 1997 ; Vol. 42, No. 1. pp. 17-23.
@article{5c64d1a163444bd7bc2a12353d9675ba,
title = "Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia",
abstract = "Intraischemic reduction in temperature of 2-3°C (modest hypothermia) has been demonstrated to provide partial neuroprotection in neonatal animals. This investigation determined if modest hypothermia initiated immediately after brain ischemia provides neuroprotection. Piglets were studied with rectal temperature maintained during the 1st h after 15 min of brain ischemia at either 38.3 ± 0.3°C (normothermia, n = 11) or at 35.8 ± 0.5°C (modest hypothermia, n = 11). The severity of brain ischemia was similar between groups as indicated by equivalent reduction in mean blood pressure (90 ± 15 to 24 ± 3 versus 92 ± 13 to 26 ± 3 mm Hg), and changes in cerebral metabolites and intracellular pH (pH(i)) measured by magnetic resonance spectroscopy (β-nucleoside triphosphate = 44 ± 9 versus 42 ± 18{\%} of control, control = 100{\%}, pH(i): 6.25 ± .15 versus 6.24 ± 0.22 for normothermic and modestly hypothermic groups, respectively). In the first 90 min after ischemia, there were no differences between groups in the duration and extent of brain acidosis, and relative concentrations of phosphorylated metabolites. Categorical assessment of neurobehavior was evaluated at 72 h postischemia (n = 16), or earlier if an animal's condition deteriorated (n = 6). Postischemic hypothermia was associated with less severe stages of encephalopathy compared with normothermia (p = 0.05). Histologic neuronal injury was assessed categorically in 16 brain regions, and postischemic hypothermia resulted in less neuronal injury in temporal (p = 0.024) and occipital (p = 0.044) cortex at 10 mm beneath the cortical surface, and in the basal ganglia (p = 0.038) compared with that in normothermia. Modest hypothermia for 1 h immediately after brain ischemia provides partial neuroprotection and may represent an adjunct to resuscitative strategies.",
author = "Laptook, {Abbot R.} and Corbett, {Ronald J T} and Rick Sterett and Burns, {Dennis K.} and Damian Garcia and Greg Tollefsbol",
year = "1997",
month = "7",
language = "English (US)",
volume = "42",
pages = "17--23",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Modest hypothermia provides partial neuroprotection when used for immediate resuscitation after brain ischemia

AU - Laptook, Abbot R.

AU - Corbett, Ronald J T

AU - Sterett, Rick

AU - Burns, Dennis K.

AU - Garcia, Damian

AU - Tollefsbol, Greg

PY - 1997/7

Y1 - 1997/7

N2 - Intraischemic reduction in temperature of 2-3°C (modest hypothermia) has been demonstrated to provide partial neuroprotection in neonatal animals. This investigation determined if modest hypothermia initiated immediately after brain ischemia provides neuroprotection. Piglets were studied with rectal temperature maintained during the 1st h after 15 min of brain ischemia at either 38.3 ± 0.3°C (normothermia, n = 11) or at 35.8 ± 0.5°C (modest hypothermia, n = 11). The severity of brain ischemia was similar between groups as indicated by equivalent reduction in mean blood pressure (90 ± 15 to 24 ± 3 versus 92 ± 13 to 26 ± 3 mm Hg), and changes in cerebral metabolites and intracellular pH (pH(i)) measured by magnetic resonance spectroscopy (β-nucleoside triphosphate = 44 ± 9 versus 42 ± 18% of control, control = 100%, pH(i): 6.25 ± .15 versus 6.24 ± 0.22 for normothermic and modestly hypothermic groups, respectively). In the first 90 min after ischemia, there were no differences between groups in the duration and extent of brain acidosis, and relative concentrations of phosphorylated metabolites. Categorical assessment of neurobehavior was evaluated at 72 h postischemia (n = 16), or earlier if an animal's condition deteriorated (n = 6). Postischemic hypothermia was associated with less severe stages of encephalopathy compared with normothermia (p = 0.05). Histologic neuronal injury was assessed categorically in 16 brain regions, and postischemic hypothermia resulted in less neuronal injury in temporal (p = 0.024) and occipital (p = 0.044) cortex at 10 mm beneath the cortical surface, and in the basal ganglia (p = 0.038) compared with that in normothermia. Modest hypothermia for 1 h immediately after brain ischemia provides partial neuroprotection and may represent an adjunct to resuscitative strategies.

AB - Intraischemic reduction in temperature of 2-3°C (modest hypothermia) has been demonstrated to provide partial neuroprotection in neonatal animals. This investigation determined if modest hypothermia initiated immediately after brain ischemia provides neuroprotection. Piglets were studied with rectal temperature maintained during the 1st h after 15 min of brain ischemia at either 38.3 ± 0.3°C (normothermia, n = 11) or at 35.8 ± 0.5°C (modest hypothermia, n = 11). The severity of brain ischemia was similar between groups as indicated by equivalent reduction in mean blood pressure (90 ± 15 to 24 ± 3 versus 92 ± 13 to 26 ± 3 mm Hg), and changes in cerebral metabolites and intracellular pH (pH(i)) measured by magnetic resonance spectroscopy (β-nucleoside triphosphate = 44 ± 9 versus 42 ± 18% of control, control = 100%, pH(i): 6.25 ± .15 versus 6.24 ± 0.22 for normothermic and modestly hypothermic groups, respectively). In the first 90 min after ischemia, there were no differences between groups in the duration and extent of brain acidosis, and relative concentrations of phosphorylated metabolites. Categorical assessment of neurobehavior was evaluated at 72 h postischemia (n = 16), or earlier if an animal's condition deteriorated (n = 6). Postischemic hypothermia was associated with less severe stages of encephalopathy compared with normothermia (p = 0.05). Histologic neuronal injury was assessed categorically in 16 brain regions, and postischemic hypothermia resulted in less neuronal injury in temporal (p = 0.024) and occipital (p = 0.044) cortex at 10 mm beneath the cortical surface, and in the basal ganglia (p = 0.038) compared with that in normothermia. Modest hypothermia for 1 h immediately after brain ischemia provides partial neuroprotection and may represent an adjunct to resuscitative strategies.

UR - http://www.scopus.com/inward/record.url?scp=0030992023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030992023&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 17

EP - 23

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 1

ER -