Modification of Na channels by synthetic dihydrobatrachotoxinin A-20 alpha-benzoate.

G. N. Mozhayeva, A. P. Naumov, E. D. Nosyreva

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Sodium channels in nodal membrane modified by a synthetic analog of batrachotoxin, 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate, were studied under voltage clamp conditions. The voltage dependence of channel activation was shifted by 70-80 mV towards more negative potentials. Selectivity sequence determined from peak current reversal potential was as follows: Na:NH4:K = 1:0.46:0.23. Our data suggest that 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate has qualitatively similar effects on the properties of sodium channels as does natural batrachotoxin.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalGeneral physiology and biophysics
Volume5
Issue number2
StatePublished - Apr 1 1986

ASJC Scopus subject areas

  • Biophysics
  • Physiology

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