Abstract
Sodium channels in nodal membrane modified by a synthetic analog of batrachotoxin, 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate, were studied under voltage clamp conditions. The voltage dependence of channel activation was shifted by 70-80 mV towards more negative potentials. Selectivity sequence determined from peak current reversal potential was as follows: Na:NH4:K = 1:0.46:0.23. Our data suggest that 7,8-dihydrobatrachotoxinin A-20 alpha-benzoate has qualitatively similar effects on the properties of sodium channels as does natural batrachotoxin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 153-158 |
| Number of pages | 6 |
| Journal | General physiology and biophysics |
| Volume | 5 |
| Issue number | 2 |
| State | Published - Apr 1 1986 |
ASJC Scopus subject areas
- Biophysics
- Physiology