Modification of the Na+ current conducted by the rat skeletal muscle α subunit by coexpression with a human brain β subunit

S. C. Cannon, A. I. McClatchey, J. F. Gusella

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Sodium channels are multimeric structures composed of α and β subunits. Oocytes injected with RNA encoding only the α subunit express voltage-gated Na+ currents. The kinetics of inactivation, however, are abnormal. Co-injection of rat brain α and β subunits modifies inactivation of INa such that it closely resembles endogenous currents [1]. Here we show that a β subunit derived from human brain directs the same functional modification of INa expressed by a rat skeletal muscle α subunit. This implies that functional domains for the interaction of α and β subunits are highly conserved across both tissues and species.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume423
Issue number1-2
DOIs
StatePublished - Apr 1993

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Muscle
Rats
Brain
Skeletal Muscle
Sodium Channels
Oocytes
RNA
Tissue
Injections
Kinetics
Electric potential

Keywords

  • skeletal muscle
  • sodium channel
  • Xenopus

ASJC Scopus subject areas

  • Physiology

Cite this

Modification of the Na+ current conducted by the rat skeletal muscle α subunit by coexpression with a human brain β subunit. / Cannon, S. C.; McClatchey, A. I.; Gusella, J. F.

In: Pflügers Archiv European Journal of Physiology, Vol. 423, No. 1-2, 04.1993, p. 155-157.

Research output: Contribution to journalArticle

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