Modification of the Na+ current conducted by the rat skeletal muscle α subunit by coexpression with a human brain β subunit

S. C. Cannon, A. I. McClatchey, J. F. Gusella

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Sodium channels are multimeric structures composed of α and β subunits. Oocytes injected with RNA encoding only the α subunit express voltage-gated Na+ currents. The kinetics of inactivation, however, are abnormal. Co-injection of rat brain α and β subunits modifies inactivation of INa such that it closely resembles endogenous currents [1]. Here we show that a β subunit derived from human brain directs the same functional modification of INa expressed by a rat skeletal muscle α subunit. This implies that functional domains for the interaction of α and β subunits are highly conserved across both tissues and species.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume423
Issue number1-2
DOIs
StatePublished - Apr 1 1993

Keywords

  • Xenopus
  • skeletal muscle
  • sodium channel

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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