Modified Beer-Lambert law for blood flow

Wesley B. Baker, Ashwin B. Parthasarathy, David R. Busch, Rickson C. Mesquita, Joel H. Greenberg, A. G. Yodh

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.

Original languageEnglish (US)
Pages (from-to)4053-4075
Number of pages23
JournalBiomedical Optics Express
Volume5
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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    Baker, W. B., Parthasarathy, A. B., Busch, D. R., Mesquita, R. C., Greenberg, J. H., & Yodh, A. G. (2014). Modified Beer-Lambert law for blood flow. Biomedical Optics Express, 5(11), 4053-4075. https://doi.org/10.1364/BOE.5.004053