Modified Beer-Lambert law for blood flow

Wesley B. Baker, Ashwin B. Parthasarathy, David R. Busch, Rickson C. Mesquita, Joel H. Greenberg, A. G. Yodh

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.

Original languageEnglish (US)
Pages (from-to)4053-4075
Number of pages23
JournalBiomedical Optics Express
Volume5
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Fingerprint

Bouguer law
blood flow
flow measurement
pressure measurement
autocorrelation
Spectrum Analysis
time lag
formulations
Light
Pressure
propagation
geometry
scattering
spectroscopy

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Baker, W. B., Parthasarathy, A. B., Busch, D. R., Mesquita, R. C., Greenberg, J. H., & Yodh, A. G. (2014). Modified Beer-Lambert law for blood flow. Biomedical Optics Express, 5(11), 4053-4075. https://doi.org/10.1364/BOE.5.004053

Modified Beer-Lambert law for blood flow. / Baker, Wesley B.; Parthasarathy, Ashwin B.; Busch, David R.; Mesquita, Rickson C.; Greenberg, Joel H.; Yodh, A. G.

In: Biomedical Optics Express, Vol. 5, No. 11, 01.11.2014, p. 4053-4075.

Research output: Contribution to journalArticle

Baker, WB, Parthasarathy, AB, Busch, DR, Mesquita, RC, Greenberg, JH & Yodh, AG 2014, 'Modified Beer-Lambert law for blood flow', Biomedical Optics Express, vol. 5, no. 11, pp. 4053-4075. https://doi.org/10.1364/BOE.5.004053
Baker WB, Parthasarathy AB, Busch DR, Mesquita RC, Greenberg JH, Yodh AG. Modified Beer-Lambert law for blood flow. Biomedical Optics Express. 2014 Nov 1;5(11):4053-4075. https://doi.org/10.1364/BOE.5.004053
Baker, Wesley B. ; Parthasarathy, Ashwin B. ; Busch, David R. ; Mesquita, Rickson C. ; Greenberg, Joel H. ; Yodh, A. G. / Modified Beer-Lambert law for blood flow. In: Biomedical Optics Express. 2014 ; Vol. 5, No. 11. pp. 4053-4075.
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