Modified Beer-Lambert law for blood flow

Wesley B. Baker; Ashwin B. Parthasarathy; David R. Busch; Rickson C. Mesquita; Joel H. Greenberg; A. G. Yodh

doi:10.1364/BOE.5.004053

Modified Beer-Lambert law for blood flow

Wesley B. Baker, Ashwin B. Parthasarathy, David R. Busch, Rickson C. Mesquita, Joel H. Greenberg, A. G. Yodh

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.

Original language	English (US)
Pages (from-to)	4053-4075
Number of pages	23
Journal	Biomedical Optics Express
Volume	5
Issue number	11
DOIs	https://doi.org/10.1364/BOE.5.004053
State	Published - Nov 1 2014
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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abstract = "We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.",

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AU - Parthasarathy, Ashwin B.

AU - Busch, David R.

AU - Mesquita, Rickson C.

AU - Greenberg, Joel H.

AU - Yodh, A. G.

PY - 2014/11/1

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AB - We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.

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Modified Beer-Lambert law for blood flow

Abstract

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