Modulation of calcium and potassium currents by lamotrigine

Heinz Grunze; Jörg Von Wegerer; Robert W. Greene; Jörg Walden

doi:10.1159/000026528

Modulation of calcium and potassium currents by lamotrigine

Heinz Grunze, Jörg Von Wegerer, Robert W. Greene, Jörg Walden

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage-gated - calcium currents and the transient potassium outward current I(D). These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder.

Original language	English (US)
Pages (from-to)	131-138
Number of pages	8
Journal	Neuropsychobiology
Volume	38
Issue number	3
DOIs	https://doi.org/10.1159/000026528
State	Published - Oct 1998

Keywords

Bipolar disorder
Calcium
Carbamazepine
Epilepsy
Lamotrigine
Potassium
Valproate
Verapamil

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Psychiatry and Mental health
Biological Psychiatry

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10.1159/000026528

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title = "Modulation of calcium and potassium currents by lamotrigine",

abstract = "Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage-gated - calcium currents and the transient potassium outward current I(D). These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder.",

keywords = "Bipolar disorder, Calcium, Carbamazepine, Epilepsy, Lamotrigine, Potassium, Valproate, Verapamil",

author = "Heinz Grunze and {Von Wegerer}, J{\"o}rg and Greene, {Robert W.} and J{\"o}rg Walden",

year = "1998",

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AU - Grunze, Heinz

AU - Von Wegerer, Jörg

AU - Greene, Robert W.

AU - Walden, Jörg

PY - 1998/10

Y1 - 1998/10

N2 - Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage-gated - calcium currents and the transient potassium outward current I(D). These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder.

AB - Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage-gated - calcium currents and the transient potassium outward current I(D). These may be effective mechanisms to inhibit pathological excitation in epilepsy and may be of potential benefit in treating underlying cellular disturbances in bipolar disorder.

KW - Bipolar disorder

KW - Calcium

KW - Carbamazepine

KW - Epilepsy

KW - Lamotrigine

KW - Potassium

KW - Valproate

KW - Verapamil

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Modulation of calcium and potassium currents by lamotrigine

Abstract

Keywords

ASJC Scopus subject areas

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